Ghaebi Mahnaz, Nouri Mohammad, Ghasemzadeh Aliyeh, Farzadi Laya, Jadidi-Niaragh Farhad, Ahmadi Majid, Yousefi Mehdi
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Biochemistry and Clinical Laboratories, Tabriz University of Medical Sciences, Tabriz, Iran.
Biomed Pharmacother. 2017 Apr;88:61-73. doi: 10.1016/j.biopha.2017.01.016. Epub 2017 Jan 14.
Maternal immune system must tolerate semiallogenic fetus to establish and maintain a successful pregnancy. Despite the existence of several strategies of trophoblast to avoid recognition by maternal leukocytes, maternal immune system may react against paternal alloantigenes. Leukocytes are important components in decidua. Not only T helper (Th)1/Th2 balance, but also regulatory T (Treg) cells play an important role in pregnancy. Although the frequency of Tregs is elevated during normal pregnancies, their frequency and function are reduced in reproductive defects such as recurrent miscarriage and preeclampsia. Tregs are not the sole population of suppressive cells in the decidua. It has recently been shown that regulatory B10 (Breg) cells participate in pregnancy through secretion of IL-10 cytokine. Myeloid derived suppressor cells (MDSCs) are immature developing precursors of innate myeloid cells that are increased in pregnant women, implying their possible function in pregnancy. Natural killer T (NKT) cells are also detected in mouse and human decidua. They can also affect the fetomaternal tolerance. In this review, we will discuss on the role of different immune regulatory cells including Treg, γd T cell, Breg, MDSC, and NKT cells in pregnancy outcome.
母体免疫系统必须耐受半同种异体胎儿以建立并维持成功的妊娠。尽管滋养层细胞存在多种避免被母体白细胞识别的策略，但母体免疫系统仍可能对父系同种异体抗原产生反应。白细胞是蜕膜中的重要组成部分。不仅辅助性T（Th）1/Th2平衡，调节性T（Treg）细胞在妊娠中也发挥着重要作用。虽然在正常妊娠期间Treg细胞的频率会升高，但在复发性流产和先兆子痫等生殖缺陷中，它们的频率和功能会降低。Treg细胞不是蜕膜中唯一的抑制性细胞群体。最近有研究表明，调节性B10（Breg）细胞通过分泌白细胞介素-10细胞因子参与妊娠过程。髓系来源的抑制性细胞（MDSC）是先天性髓系细胞未成熟的发育前体，在孕妇中数量增加，这暗示了它们在妊娠中的可能作用。自然杀伤性T（NKT）细胞也在小鼠和人类蜕膜中被检测到。它们也会影响母胎耐受。在本综述中，我们将讨论不同免疫调节细胞，包括Treg细胞、γδT细胞、Breg细胞、MDSC和NKT细胞在妊娠结局中的作用。
