Laijawala Riddhi A
Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, United Kingdom.
Brain Behav Immun Health. 2024 Sep 19;41:100868. doi: 10.1016/j.bbih.2024.100868. eCollection 2024 Nov.
Recurrent pregnancy loss (RPL) is an obstetric condition estimated to affect 2-4% of childbearing individuals globally. Due to its varied nature, medical societies globally differ in their diagnostic criteria. Its aetiologies are numerous, ranging from anatomic abnormalities to endocrine and immunological factors. Autoimmune factors can attribute to approximately 20% of cases and include dysregulation of immune cells, cytokine production and antiphospholipid syndrome. Treatment pathways vary by aetiology; however, many cases remain unexplained, adding an additional level of complexity to this condition. Due to its recurrent nature, this type of pregnancy loss has profound impacts on mental health during subsequent pregnancies. While some aspects of RPL have been widely investigated, there continues to be a gap in research, such as its impacts on non-birthing parents and specific sociodemographic groups.
复发性流产（RPL）是一种产科疾病，据估计全球有2%-4%的育龄人群受其影响。由于其性质多样，全球各医学协会的诊断标准存在差异。其病因众多，从解剖异常到内分泌和免疫因素不等。自身免疫因素约占病例的20%，包括免疫细胞失调、细胞因子产生和抗磷脂综合征。治疗途径因病因而异；然而，许多病例仍无法解释，这给这种疾病增添了额外的复杂性。由于其复发性，这种类型的流产对后续妊娠期间的心理健康有深远影响。虽然复发性流产的一些方面已得到广泛研究，但在研究方面仍存在差距，例如其对非生育父母和特定社会人口群体的影响。
