广藿香醇与β-环糊精包合物的研究。

Xu Fangfang, Yang Qiuxia, Wu Lilan, Qi Rui, Wu Yunshan, Li Yucui, Tang Lipeng, Guo De-An, Liu Bo

The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China.

Guangdong Pharmaceutical University, College of Traditional Chinese Medicine, Guangzhou, China.

PLoS One. 2017 Jan 17;12(1):e0169578. doi: 10.1371/journal.pone.0169578. eCollection 2017.

The objective of this study was to improve the stability and water-solubility of patchouli alcohol by complexing with β-cyclodextrin (β-CD). The interactions between patchouli alcohol and β-CD were characterized by differential scanning calorimetry (DSC), Fourier transformation-infrared (FT-IR) spectroscopy, powder X-ray diffraction (PXRD), and Scanning electron microscope (SEM), respectively. According to molecular modeling method, the enthalpy formation of host-guest illustrated the predominant configuration and the lowest value ΔbGo was -10.8174±1.9235 kcal/mol, suggesting the complex could reduce the energy of the system. The characterization analysis confirmed the formation of PA-CD inclusion complex, and the results indicated the advantage of the inclusion complex in stability and dissolution rates. These results identified PA-CD inclusion complex an effective way for the storage of PA, and better inclusion method still needed to be studied.

本研究的目的是通过与β-环糊精（β-CD）络合来提高广藿香醇的稳定性和水溶性。分别采用差示扫描量热法（DSC）、傅里叶变换红外光谱（FT-IR）、粉末X射线衍射（PXRD）和扫描电子显微镜（SEM）对广藿香醇与β-CD之间的相互作用进行了表征。根据分子建模方法，主客体的焓形成说明了主要构型，最低值ΔbGo为-10.8174±1.9235 kcal/mol，表明该络合物可以降低系统能量。表征分析证实了PA-CD包合物的形成，结果表明包合物在稳定性和溶解速率方面具有优势。这些结果确定了PA-CD包合物是储存PA的有效方法，仍需要研究更好的包合方法。