一个古老的RNA结合蛋白家族：仍然很重要！
An Ancient Family of RNA-Binding Proteins: Still Important!
作者信息
Wells Melissa L, Perera Lalith, Blackshear Perry J
机构信息
Signal Transduction Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
出版信息
Trends Biochem Sci. 2017 Apr;42(4):285-296. doi: 10.1016/j.tibs.2016.12.003. Epub 2017 Jan 14.
Abstract
RNA-binding proteins are important modulators of mRNA stability, a crucial process that determines the ultimate cellular levels of mRNAs and their encoded proteins. The tristetraprolin (TTP) family of RNA-binding proteins appeared early in the evolution of eukaryotes, and has persisted in modern eukaryotes. The domain structures and biochemical functions of family members from widely divergent lineages are remarkably similar, but their mRNA 'targets' can be very different, even in closely related species. Recent gene knockout studies in species as distantly related as plants, flies, yeasts, and mice have demonstrated crucial roles for these proteins in a wide variety of physiological processes. Inflammatory and hematopoietic phenotypes in mice have suggested potential therapeutic approaches for analogous human disorders.
摘要
RNA结合蛋白是mRNA稳定性的重要调节因子，mRNA稳定性是一个关键过程，它决定了mRNA及其编码蛋白在细胞中的最终水平。RNA结合蛋白的三联四脯氨酸（TTP）家族在真核生物进化早期就已出现，并在现代真核生物中一直存在。来自广泛不同谱系的家族成员的结构域结构和生化功能非常相似，但它们的mRNA“靶点”可能非常不同，即使在亲缘关系很近的物种中也是如此。最近在植物、果蝇、酵母和小鼠等亲缘关系很远的物种中进行的基因敲除研究表明，这些蛋白在多种生理过程中发挥着关键作用。小鼠的炎症和造血表型为类似人类疾病提供了潜在的治疗方法。
相似文献
1
An Ancient Family of RNA-Binding Proteins: Still Important!一个古老的RNA结合蛋白家族：仍然很重要！
Trends Biochem Sci. 2017 Apr;42(4):285-296. doi: 10.1016/j.tibs.2016.12.003. Epub 2017 Jan 14.
2
The tandem zinc finger RNA binding domain of members of the tristetraprolin protein family.三肽重复蛋白家族成员的串联锌指 RNA 结合结构域。
Wiley Interdiscip Rev RNA. 2019 Jul;10(4):e1531. doi: 10.1002/wrna.1531. Epub 2019 Mar 12.
3
Phylogenetic distribution and evolution of the linked RNA-binding and NOT1-binding domains in the tristetraprolin family of tandem CCCH zinc finger proteins.串联CCCH锌指蛋白Tristetraprolin家族中与RNA结合和NOT1结合结构域的系统发育分布及进化
J Interferon Cytokine Res. 2014 Apr;34(4):297-306. doi: 10.1089/jir.2013.0150.
4
Chorioallantoic fusion defects and embryonic lethality resulting from disruption of Zfp36L1, a gene encoding a CCCH tandem zinc finger protein of the Tristetraprolin family.Zfp36L1基因（一种编码Tristetraprolin家族CCCH串联锌指蛋白的基因）的破坏导致绒毛膜尿囊融合缺陷和胚胎致死性。
Mol Cell Biol. 2004 Jul;24(14):6445-55. doi: 10.1128/MCB.24.14.6445-6455.2004.
5
Importance of the Conserved Carboxyl-Terminal CNOT1 Binding Domain to Tristetraprolin Activity .保守的羧基末端 CNOT1 结合域对 Tristetraprolin 活性的重要性。
Mol Cell Biol. 2019 Jun 13;39(13). doi: 10.1128/MCB.00029-19. Print 2019 Jul 1.
6
Interactions of CCCH zinc finger proteins with mRNA: tristetraprolin-mediated AU-rich element-dependent mRNA degradation can occur in the absence of a poly(A) tail.CCCH锌指蛋白与信使核糖核酸的相互作用：在没有聚腺苷酸尾的情况下，由锌指蛋白介导的富含AU元件的信使核糖核酸依赖性降解仍可发生。
J Biol Chem. 2001 Jun 22;276(25):23144-54. doi: 10.1074/jbc.M100680200. Epub 2001 Mar 28.
7
Expression, purification, and biochemical characterization of the antiinflammatory tristetraprolin: a zinc-dependent mRNA binding protein affected by posttranslational modifications.抗炎蛋白Tristetraprolin的表达、纯化及生化特性：一种受翻译后修饰影响的锌依赖性mRNA结合蛋白
Biochemistry. 2004 Nov 2;43(43):13724-38. doi: 10.1021/bi049014y.
8
The Drosophila Tis11 protein and its effects on mRNA expression in flies.果蝇Tis11蛋白及其对果蝇mRNA表达的影响。
J Biol Chem. 2014 Dec 19;289(51):35042-60. doi: 10.1074/jbc.M114.593491. Epub 2014 Oct 23.
9
Conceptual Advances in Control of Inflammation by the RNA-Binding Protein Tristetraprolin.TRISTETRAPROLIN 通过 RNA 结合蛋白控制炎症的概念性进展。
Front Immunol. 2021 Sep 17;12:751313. doi: 10.3389/fimmu.2021.751313. eCollection 2021.
10
Backbone and sidechain H, N and C resonance assignments of the free and RNA-bound tandem zinc finger domain of the tristetraprolin family member from Selaginella moellendorffii.来自卷柏属植物的三聚体蛋白家族成员的游离和 RNA 结合串联锌指结构域的骨架和侧链 H、N 和 C 共振分配。
Biomol NMR Assign. 2022 Apr;16(1):153-158. doi: 10.1007/s12104-022-10073-8. Epub 2022 Mar 12.
引用本文的文献
1
Multivalent interactions with CCR4-NOT and PABPC1 determine mRNA repression efficiency by tristetraprolin.与CCR4-NOT和PABPC1的多价相互作用决定了锌指蛋白对mRNA的抑制效率。
Nat Commun. 2025 Aug 13;16(1):7528. doi: 10.1038/s41467-025-62741-7.
2
Gene Expression Signatures of Porcine Bone Marrow-Derived Antigen-Presenting Cells Infected with Classical Swine Fever Virus.感染经典猪瘟病毒的猪骨髓来源抗原呈递细胞的基因表达特征
Viruses. 2025 Jan 24;17(2):160. doi: 10.3390/v17020160.
3
Ectopic expression of gene from human in poplar promotes xylem differentiation and confers plant drought tolerance.人类基因在杨树中的异位表达促进木质部分化并赋予植物耐旱性。
For Res (Fayettev). 2024 Apr 9;4:e011. doi: 10.48130/forres-0024-0008. eCollection 2024.
4
The Inhibition of Gag-Pol Expression by the Restriction Factor Shiftless Is Dispensable for the Restriction of HIV-1 Infection.限制因子Shiftless对Gag-Pol表达的抑制作用对于HIV-1感染的限制是可有可无的。
Viruses. 2024 Apr 10;16(4):583. doi: 10.3390/v16040583.
5
Insights into the regulatory role of RNA methylation modifications in glioma.揭示 RNA 甲基化修饰在神经胶质瘤中的调控作用。
J Transl Med. 2023 Nov 14;21(1):810. doi: 10.1186/s12967-023-04653-y.
6
Synergistic roles of tristetraprolin family members in myeloid cells in the control of inflammation.三肽重复蛋白家族成员在髓系细胞中对炎症控制的协同作用。
Life Sci Alliance. 2023 Oct 30;7(1). doi: 10.26508/lsa.202302222. Print 2024 Jan.
7
Regulatory and pathogenic mechanisms in response to iron deficiency and excess in fungi.真菌应对缺铁和铁过量的调控和致病机制。
Microb Biotechnol. 2023 Nov;16(11):2053-2071. doi: 10.1111/1751-7915.14346. Epub 2023 Oct 7.
8
Multiomics analysis couples mRNA turnover and translational control of glutamine metabolism to the differentiation of the activated CD4 T cell.多组学分析将 mRNA 周转率和谷氨酰胺代谢的翻译控制与激活的 CD4 T 细胞的分化联系起来。
Sci Rep. 2022 Nov 16;12(1):19657. doi: 10.1038/s41598-022-24132-6.
9
Intrinsically disordered regions of tristetraprolin and DCP2 directly interact to mediate decay of ARE-mRNA.Tristetraprolin 和 DCP2 的无规则区域直接相互作用，介导 ARE-mRNA 的降解。
Nucleic Acids Res. 2022 Oct 14;50(18):10665-10679. doi: 10.1093/nar/gkac797.
10
Induction of a colitogenic phenotype in Th1-like cells depends on interleukin-23 receptor signaling.Th1 样细胞中致结肠炎表型的诱导依赖于白细胞介素-23 受体信号。
Immunity. 2022 Sep 13;55(9):1663-1679.e6. doi: 10.1016/j.immuni.2022.08.007. Epub 2022 Sep 6.
本文引用的文献
1
A Novel Hybrid Iron Regulation Network Combines Features from Pathogenic and Nonpathogenic Yeasts.一种新型混合铁调节网络融合了致病酵母和非致病酵母的特征。
mBio. 2016 Oct 18;7(5):e01782-16. doi: 10.1128/mBio.01782-16.
2
AUF1 regulation of coding and noncoding RNA.AUF1对编码RNA和非编码RNA的调控
Wiley Interdiscip Rev RNA. 2017 Mar;8(2). doi: 10.1002/wrna.1393. Epub 2016 Sep 13.
3
Tristetraprolin binding site atlas in the macrophage transcriptome reveals a switch for inflammation resolution.巨噬细胞转录组中的锌指蛋白结合位点图谱揭示了炎症消退的转换机制。
Mol Syst Biol. 2016 May 13;12(5):868. doi: 10.15252/msb.20156628.
4
RNA-binding proteins ZFP36L1 and ZFP36L2 promote cell quiescence.RNA 结合蛋白 ZFP36L1 和 ZFP36L2 促进细胞静止。
Science. 2016 Apr 22;352(6284):453-9. doi: 10.1126/science.aad5978.
5
Deficiency of the placenta- and yolk sac-specific tristetraprolin family member ZFP36L3 identifies likely mRNA targets and an unexpected link to placental iron metabolism.胎盘和卵黄囊特异性的锌指蛋白36样蛋白3（Tristetraprolin family member ZFP36L3）缺乏可确定可能的mRNA靶点以及与胎盘铁代谢的意外关联。
Development. 2016 Apr 15;143(8):1424-33. doi: 10.1242/dev.130369. Epub 2016 Mar 7.
6
Enhanced stability of tristetraprolin mRNA protects mice against immune-mediated inflammatory pathologies.三氧化四脯氨酸信使核糖核酸（Tristetraprolin mRNA）稳定性的增强可保护小鼠免受免疫介导的炎症性疾病侵害。
Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):1865-70. doi: 10.1073/pnas.1519906113. Epub 2016 Feb 1.
7
Recruitment of the 4EHP-GYF2 cap-binding complex to tetraproline motifs of tristetraprolin promotes repression and degradation of mRNAs with AU-rich elements.4EHP-GYF2帽结合复合物被招募至锌指蛋白TTP的四脯氨酸基序，可促进富含AU元件的mRNA的抑制和降解。
RNA. 2016 Mar;22(3):373-82. doi: 10.1261/rna.054833.115. Epub 2016 Jan 13.
8
Emergence and evolution of Zfp36l3.锌指蛋白36样蛋白3（Zfp36l3）的出现与进化
Mol Phylogenet Evol. 2016 Jan;94(Pt B):518-530. doi: 10.1016/j.ympev.2015.10.016. Epub 2015 Oct 19.
9
Functional equivalence of an evolutionarily conserved RNA binding module.一个进化上保守的RNA结合模块的功能等效性。
J Biol Chem. 2015 Oct 2;290(40):24413-23. doi: 10.1074/jbc.M115.673012. Epub 2015 Aug 19.
10
RNA binding proteins as regulators of immune cell biology.作为免疫细胞生物学调节因子的RNA结合蛋白
Clin Exp Immunol. 2016 Jan;183(1):37-49. doi: 10.1111/cei.12684. Epub 2015 Sep 11.
Zotero 插件