作为免疫细胞生物学调节因子的RNA结合蛋白
RNA binding proteins as regulators of immune cell biology.
作者信息
Newman R, McHugh J, Turner M
机构信息
Babraham Institute, Cambridge, UK.
出版信息
Clin Exp Immunol. 2016 Jan;183(1):37-49. doi: 10.1111/cei.12684. Epub 2015 Sep 11.
Abstract
Sequence-specific RNA binding proteins (RBP) are important regulators of the immune response. RBP modulate gene expression by regulating splicing, polyadenylation, localization, translation and decay of target mRNAs. Increasing evidence suggests that RBP play critical roles in the development, activation and function of lymphocyte populations in the immune system. This review will discuss the post-transcriptional regulation of gene expression by RBP during lymphocyte development, with particular focus on the Tristetraprolin family of RBP.
摘要
序列特异性RNA结合蛋白（RBP）是免疫反应的重要调节因子。RBP通过调节靶mRNA的剪接、聚腺苷酸化、定位、翻译和降解来调控基因表达。越来越多的证据表明，RBP在免疫系统中淋巴细胞群体的发育、激活和功能中发挥关键作用。本综述将讨论RBP在淋巴细胞发育过程中对基因表达的转录后调控，尤其关注RBP的Tristetraprolin家族。
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