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1
Dual-Specificity Phosphatase 1 and Tristetraprolin Cooperate To Regulate Macrophage Responses to Lipopolysaccharide.双特异性磷酸酶1与锌指蛋白Tristetraprolin协同调节巨噬细胞对脂多糖的反应。
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Dominant Suppression of Inflammation via Targeted Mutation of the mRNA Destabilizing Protein Tristetraprolin.通过对mRNA去稳定蛋白Tristetraprolin进行靶向突变对炎症进行显性抑制。
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The RNA-binding protein HuR is essential for the B cell antibody response.RNA结合蛋白HuR对B细胞抗体反应至关重要。
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Deletion of AU-rich elements within the Bcl2 3'UTR reduces protein expression and B cell survival in vivo.删除Bcl2 3'非翻译区（3'UTR）内富含AU的元件可降低体内蛋白质表达和B细胞存活率。
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Splice factor mutations and alternative splicing as drivers of hematopoietic malignancy.剪接因子突变和可变剪接作为造血系统恶性肿瘤的驱动因素。
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PAR-CLIP analysis uncovers AUF1 impact on target RNA fate and genome integrity.PAR-CLIP分析揭示了AUF1对靶RNA命运和基因组完整性的影响。
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A census of human RNA-binding proteins.人类 RNA 结合蛋白普查。
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8
Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote T(H)17 differentiation.颗粒酶和 REGNase-1 由 MALT1 半胱天冬酶切割，释放其协同抑制的靶标，以促进 TH17 分化。
Nat Immunol. 2014 Nov;15(11):1079-89. doi: 10.1038/ni.3008. Epub 2014 Oct 5.
9
Rapid proteasomal degradation of posttranscriptional regulators of the TIS11/tristetraprolin family is induced by an intrinsically unstructured region independently of ubiquitination.TIS11/三叶草蛋白家族转录后调节因子的快速蛋白酶体降解是由一个内在无序区域独立于泛素化诱导的。
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7SL RNA represses p53 translation by competing with HuR.7SL RNA通过与HuR竞争来抑制p53的翻译。
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作为免疫细胞生物学调节因子的RNA结合蛋白

RNA binding proteins as regulators of immune cell biology.

作者信息

Newman R, McHugh J, Turner M

机构信息

Babraham Institute, Cambridge, UK.

出版信息

Clin Exp Immunol. 2016 Jan;183(1):37-49. doi: 10.1111/cei.12684. Epub 2015 Sep 11.

DOI:10.1111/cei.12684
PMID:26201441
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4687516/
Abstract

Sequence-specific RNA binding proteins (RBP) are important regulators of the immune response. RBP modulate gene expression by regulating splicing, polyadenylation, localization, translation and decay of target mRNAs. Increasing evidence suggests that RBP play critical roles in the development, activation and function of lymphocyte populations in the immune system. This review will discuss the post-transcriptional regulation of gene expression by RBP during lymphocyte development, with particular focus on the Tristetraprolin family of RBP.

摘要

序列特异性RNA结合蛋白（RBP）是免疫反应的重要调节因子。RBP通过调节靶mRNA的剪接、聚腺苷酸化、定位、翻译和降解来调控基因表达。越来越多的证据表明，RBP在免疫系统中淋巴细胞群体的发育、激活和功能中发挥关键作用。本综述将讨论RBP在淋巴细胞发育过程中对基因表达的转录后调控，尤其关注RBP的Tristetraprolin家族。