……中的转化生长因子-β家族
The TGF-β Family in .
作者信息
Savage-Dunn Cathy, Padgett Richard W
机构信息
Department of Biology, Queens College, and the Graduate Center, New York, New York 11367.
Waksman Institute, Department of Molecular Biology and Biochemistry, Cancer Institute of New Jersey, Rutgers University, Piscataway, New Jersey 08854-8020.
出版信息
Cold Spring Harb Perspect Biol. 2017 Jun 1;9(6):a022178. doi: 10.1101/cshperspect.a022178.
Abstract
Transforming growth factor β (TGF-β) and related ligands have potent effects on an enormous diversity of biological functions in all animals examined. Because of the strong conservation of TGF-β family ligand functions and signaling mechanisms, studies from multiple animal systems have yielded complementary and synergistic insights. In the nematode , early studies were instrumental in the elucidation of TGF-β family signaling mechanisms. Current studies in continue to identify new functions for the TGF-β family in this organism as well as new conserved mechanisms of regulation.
摘要
转化生长因子β（TGF-β）及相关配体对所有已研究动物的众多生物学功能都有强大作用。由于TGF-β家族配体功能和信号传导机制具有高度保守性，来自多个动物系统的研究产生了互补且协同的见解。在秀丽隐杆线虫中，早期研究对线虫TGF-β家族信号传导机制的阐明起到了重要作用。目前对线虫的研究仍在不断发现TGF-β家族在该生物体中的新功能以及新的保守调控机制。
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