Yamanouchi H, Sugiura S, Tomonaga M
Department of Neurology, Tokyo Metropolitan Geriatric Hospital, Japan.
J Neurol. 1989 Oct;236(7):382-7. doi: 10.1007/BF00314894.
To study white matter changes in the frontal lobes and to investigate the histopathological basis for the dementia in progressive subcortical vascular encephalopathy (PSVE), the frontal white matter was examined by electron microscopy in seven cases with PSVE, and compared with that in a control group and in cases with senile dementia of Alzheimer's type (SDAT). The number of nerve fibres per unit selected area of the white matter was significantly less in PSVE compared with that in the control group or in SDAT. Nerve fibres in PSVE had a tendency to have thinner myelin sheaths than in the control group or in SDAT, but the difference was not significant. The pallor of the frontal white matter in PSVE is mainly based on the loss of nerve fibres, and may be in part based on the thin myelin sheaths. The dementia in PSVE is probably related to the loss of nerve fibres in the cerebral white matter.
为研究进行性皮质下血管性脑病（PSVE）额叶白质的变化，并探讨其痴呆的组织病理学基础，对7例PSVE患者的额叶白质进行了电子显微镜检查，并与对照组及阿尔茨海默型老年性痴呆（SDAT）患者进行了比较。与对照组或SDAT患者相比，PSVE患者白质单位选定区域内的神经纤维数量显著减少。与对照组或SDAT患者相比，PSVE患者的神经纤维髓鞘有变薄的趋势，但差异不显著。PSVE患者额叶白质的苍白主要基于神经纤维的丧失，部分可能基于髓鞘变薄。PSVE患者的痴呆可能与脑白质神经纤维的丧失有关。
