Mormann Florian, Kornblith Simon, Cerf Moran, Ison Matias J, Kraskov Alexander, Tran Michelle, Knieling Simeon, Quian Quiroga Rodrigo, Koch Christof, Fried Itzhak
Department of Epileptology, University of Bonn, 53105 Bonn, Germany;
Division of Biology, California Institute of Technology, Pasadena, CA 91125.
Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):1153-1158. doi: 10.1073/pnas.1608159113. Epub 2017 Jan 17.
Imaging, electrophysiological, and lesion studies have shown a relationship between the parahippocampal cortex (PHC) and the processing of spatial scenes. Our present knowledge of PHC, however, is restricted to the macroscopic properties and dynamics of bulk tissue; the behavior and selectivity of single parahippocampal neurons remains largely unknown. In this study, we analyzed responses from 630 parahippocampal neurons in 24 neurosurgical patients during visual stimulus presentation. We found a spatially clustered subpopulation of scene-selective units with an associated event-related field potential. These units form a population code that is more distributed for scenes than for other stimulus categories, and less sparse than elsewhere in the medial temporal lobe. Our electrophysiological findings provide insight into how individual units give rise to the population response observed with functional imaging in the parahippocampal place area.
影像学、电生理学和损伤研究表明，海马旁皮质（PHC）与空间场景处理之间存在关联。然而，我们目前对PHC的了解仅限于大块组织的宏观特性和动态；单个海马旁神经元的行为和选择性在很大程度上仍不清楚。在本研究中，我们分析了24例神经外科患者在视觉刺激呈现期间630个海马旁神经元的反应。我们发现了一个具有相关事件相关场电位的场景选择性单元的空间聚集亚群。这些单元形成了一种群体编码，与其他刺激类别相比，场景的群体编码分布更广泛，且比内侧颞叶其他部位的稀疏性更低。我们的电生理学研究结果为单个单元如何产生在海马旁位置区功能成像中观察到的群体反应提供了见解。
