Seo Mirinae, Ryu Jung Kyu, Jahng Geon-Ho, Sohn Yu-Mee, Rhee Sun Jung, Oh Jang-Hoon, Won Kyu-Yeoun
Department of Radiology, Kyung Hee University Hospital, College of Medicine, Kyung Hee University, Seoul 02447, Korea.
Department of Radiology, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University, Seoul 05278, Korea.
Korean J Radiol. 2017 Jan-Feb;18(1):238-248. doi: 10.3348/kjr.2017.18.1.238. Epub 2017 Jan 5.
The purpose of this study was to estimate the T2* relaxation time in breast cancer, and to evaluate the association between the T2* value with clinical-imaging-pathological features of breast cancer.
Between January 2011 and July 2013, 107 consecutive women with 107 breast cancers underwent multi-echo T2*-weighted imaging on a 3T clinical magnetic resonance imaging system. The Student's test and one-way analysis of variance were used to compare the T2* values of cancer for different groups, based on the clinical-imaging-pathological features. In addition, multiple linear regression analysis was performed to find independent predictive factors associated with the T2* values.
Of the 107 breast cancers, 92 were invasive and 15 were ductal carcinoma (DCIS). The mean T2* value of invasive cancers was significantly longer than that of DCIS ( = 0.029). Signal intensity on T2-weighted imaging (T2WI) and histologic grade of invasive breast cancers showed significant correlation with T2* relaxation time in univariate and multivariate analysis. Breast cancer groups with higher signal intensity on T2WI showed longer T2* relaxation time ( = 0.005). Cancer groups with higher histologic grade showed longer T2* relaxation time ( = 0.017).
The T2* value is significantly longer in invasive cancer than in DCIS. In invasive cancers, T2* relaxation time is significantly longer in higher histologic grades and high signal intensity on T2WI. Based on these preliminary data, quantitative T2* mapping has the potential to be useful in the characterization of breast cancer.
本研究旨在估计乳腺癌的T2弛豫时间，并评估T2值与乳腺癌临床-影像-病理特征之间的关联。
2011年1月至2013年7月期间，107例患有107个乳腺癌的连续女性患者在3T临床磁共振成像系统上接受了多回波T2加权成像。基于临床-影像-病理特征，采用Student's检验和单因素方差分析比较不同组别的癌症T2值。此外，进行多元线性回归分析以寻找与T2*值相关的独立预测因素。
107个乳腺癌中，92个为浸润性癌，15个为导管原位癌（DCIS）。浸润性癌的平均T2值显著长于DCIS（P = 0.029）。在单因素和多因素分析中，浸润性乳腺癌的T2加权成像（T2WI）信号强度和组织学分级与T2弛豫时间显示出显著相关性。T2WI上信号强度较高的乳腺癌组显示出更长的T2弛豫时间（P = 0.005）。组织学分级较高的癌症组显示出更长的T2弛豫时间（P = 0.017）。
浸润性癌的T2值显著长于DCIS。在浸润性癌中，组织学分级较高和T2WI上高信号强度的T2弛豫时间显著更长。基于这些初步数据，定量T2*成像有可能用于乳腺癌的特征描述。
