在没有疟疾传播的情况下，对候选疫苗抗原的干扰素反应会降低。
Interferon- responses to vaccine candidate antigens decrease in the absence of malaria transmission.
作者信息
Ayieko Cyrus, Ogola Bilha S, Ochola Lyticia, Ngwena Gideon A M, Ayodo George, Hodges James S, Noland Gregory S, John Chandy C
机构信息
Department of Zoology, Maseno University, Maseno, Kenya.
Department of Biological Sciences, Masai Mara University, Narok, Kenya.
出版信息
PeerJ. 2017 Jan 10;5:e2855. doi: 10.7717/peerj.2855. eCollection 2017.
BACKGROUND
Malaria elimination campaigns are planned or active in many countries. The effects of malaria elimination on immune responses such as antigen-specific IFN- responses are not well characterized.
METHODS
IFN- responses to the antigens circumsporozoite protein, liver stage antigen-1, thrombospondin-related adhesive protein, apical membrane antigen-1, MB2, and merozoite surface protein-1 were tested by ELISA in 243 individuals in highland Kenya in April 2008, October 2008, and April 2009, after a one-year period of interrupted malaria transmission from April 2007 to March 2008.
RESULTS
While one individual (0.4%) tested positive for by PCR inOctober 2008 and another two (0.9%) tested positive in April 2009, no clinical malaria cases were detected during weekly visits. Levels of IFN- to all antigens decreased significantly from April 2008 to April 2009 (all < 0.001).
DISCUSSION
Naturally acquired IFN- responses to antigensare short-lived in the absence of repeated infection. Even short periods of malaria interruption may significantly decrease IFN- responses to antigens.
背景
许多国家都在规划或开展疟疾消除运动。疟疾消除对免疫反应（如抗原特异性干扰素γ反应）的影响尚未得到充分表征。
方法
2008年4月、2008年10月和2009年4月，在肯尼亚高地的243名个体中，通过酶联免疫吸附测定法（ELISA）检测了对环子孢子蛋白、肝期抗原-1、血小板反应蛋白相关黏附蛋白、顶膜抗原-1、MB2和裂殖子表面蛋白-1等抗原的干扰素γ反应，此前从2007年4月到2008年3月经历了为期一年的疟疾传播中断期。
结果
虽然2008年10月有1名个体（0.4%）通过聚合酶链反应（PCR）检测出疟原虫阳性，2009年4月有另外2名个体（0.9%）检测出阳性，但在每周的访视中未发现临床疟疾病例。从2008年4月到2009年4月，对所有抗原的干扰素γ水平均显著下降（所有P<0.001）。
讨论
在没有反复疟原虫感染的情况下，自然获得的针对疟原虫抗原的干扰素γ反应是短暂的。即使是短时间的疟疾传播中断也可能显著降低针对疟原虫抗原的干扰素γ反应。
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