Suppr超能文献

0至2岁婴儿产前暴露于疟疾的临床疟疾发作期间的干扰素和白细胞介素-10反应：坦桑尼亚出生队列研究

Interferon- and Interleukin-10 Responses during Clinical Malaria Episodes in Infants Aged 0-2 Years Prenatally Exposed to : Tanzanian Birth Cohort.

作者信息

Sylvester Boniphace, Gasarasi Dinah B, Aboud Said, Tarimo Donath, Masawe Siriel, Mpembeni Rose, Swedberg Göte

机构信息

Department of Parasitology and Medical Entomology, School of Public Health and Social Sciences, Muhimbili University of Health and Allied Sciences, P.O. Box 65001, Dar es Salaam, Tanzania.

Department of Microbiology and Immunology, School of Medicine, Muhimbili University of Health and Allied Sciences, P.O. Box 65001, Dar es Salaam, Tanzania.

出版信息

J Trop Med. 2018 Jul 30;2018:6847498. doi: 10.1155/2018/6847498. eCollection 2018.

DOI:10.1155/2018/6847498
PMID:30154871
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6091450/
Abstract

BACKGROUND

Infants born to mothers with placental malaria are prenatally exposed to antigens. However, the effect of that exposure to subsequent immune responses has not been fully elucidated. This study aimed at determining the effect of prenatal exposure to on Interleukin-10 and Interferon- responses during clinical malaria episodes in the first 24 months of life.

METHODS

This prospective cohort study involved 215 infants aged 0-2 years born to mothers with or without placental malaria. Enzyme-linked immunosorbent assay (ELISA) was used to determine levels of IL-10 and IFN- in infants and detect IgM in cord blood. Data were analyzed using SPSS version 20.

FINDINGS

Geometric mean for IFN- in exposed infants was 557.9 pg/ml (95% CI: 511.6-604.1) and in unexposed infants it was 634.4 pg/ml (95% CI: 618.2-668.5) (P=0.02). Mean IL-10 was 22.4 pg/ml (95% CI: 19.4-28.4) and 15.1 pg/ml (95%CI: 12.4-17.6), respectively (P=0.01).

CONCLUSIONS

Prenatal exposure to antigens significantly affects IL-10 and IFN- responses during clinical malaria episodes in the first two years of life.

摘要

背景

患有胎盘疟疾的母亲所生婴儿在出生前会接触到抗原。然而，这种接触对后续免疫反应的影响尚未完全阐明。本研究旨在确定出生前接触抗原对生命最初24个月临床疟疾发作期间白细胞介素-10和干扰素反应的影响。

方法

这项前瞻性队列研究纳入了215名0至2岁的婴儿，其母亲患有或未患有胎盘疟疾。采用酶联免疫吸附测定（ELISA）法测定婴儿白细胞介素-10和干扰素水平，并检测脐血中的IgM。使用SPSS 20版软件进行数据分析。

结果

接触抗原婴儿的干扰素几何平均水平为557.9 pg/ml（95%置信区间：511.6 - 604.1），未接触抗原婴儿的该水平为634.4 pg/ml（95%置信区间：618.2 - 668.5）（P = 0.02）。白细胞介素-10的平均水平分别为22.4 pg/ml（95%置信区间：19.4 - 28.4）和15.1 pg/ml（95%置信区间：12.4 - 17.6）（P = 0.01）。

结论

出生前接触抗原会显著影响生命最初两年临床疟疾发作期间的白细胞介素-10和干扰素反应。

相似文献

1
Interferon- and Interleukin-10 Responses during Clinical Malaria Episodes in Infants Aged 0-2 Years Prenatally Exposed to : Tanzanian Birth Cohort.0至2岁婴儿产前暴露于疟疾的临床疟疾发作期间的干扰素和白细胞介素-10反应：坦桑尼亚出生队列研究
J Trop Med. 2018 Jul 30;2018:6847498. doi: 10.1155/2018/6847498. eCollection 2018.
2
Prenatal exposure to Plasmodium falciparum increases frequency and shortens time from birth to first clinical malaria episodes during the first two years of life: prospective birth cohort study.产前暴露于恶性疟原虫会增加频率并缩短出生至两岁期间首次临床疟疾发作的时间：前瞻性出生队列研究。
Malar J. 2016 Jul 22;15(1):379. doi: 10.1186/s12936-016-1417-0.
3
Hyperparasitaemia during clinical malaria episodes in infants aged 0-24 months and its association with in utero exposure to Plasmodium falciparum.0至24个月婴儿临床疟疾发作期间的高疟原虫血症及其与子宫内暴露于恶性疟原虫的关联。
BMC Res Notes. 2018 Apr 4;11(1):232. doi: 10.1186/s13104-018-3339-0.
4
Studies on Plasmodium falciparum isotypic antibodies and numbers of IL-4 and IFN-gamma secreting cells in paired maternal cord blood from South West Cameroon.喀麦隆西南部母婴配对脐带血中恶性疟原虫同种型抗体以及白细胞介素-4和γ-干扰素分泌细胞数量的研究。
Int J Infect Dis. 2005 May;9(3):159-69. doi: 10.1016/j.ijid.2004.06.012.
5
IFN-gamma and IL-10 mediate parasite-specific immune responses of cord blood cells induced by pregnancy-associated Plasmodium falciparum malaria.γ干扰素和白细胞介素-10介导由妊娠相关恶性疟原虫疟疾诱导的脐血细胞的寄生虫特异性免疫反应。
J Immunol. 2005 Feb 1;174(3):1738-45. doi: 10.4049/jimmunol.174.3.1738.
6
The Plasmodium falciparum Antigen MB2 Induces Interferon-γ and Interleukin-10 Responses in Adults in Malaria Endemic Areas of Western Kenya.恶性疟原虫抗原MB2在肯尼亚西部疟疾流行地区的成年人中诱导γ干扰素和白细胞介素-10反应。
J Glob Infect Dis. 2013 Oct;5(4):131-7. doi: 10.4103/0974-777X.122001.
7
Maternal placental infection with Plasmodium falciparum and malaria morbidity during the first 2 years of life.母亲感染恶性疟原虫的胎盘感染情况及儿童出生后头两年的疟疾发病率
Am J Epidemiol. 1997 Nov 15;146(10):826-31. doi: 10.1093/oxfordjournals.aje.a009200.
8
Changes in antigen-specific cytokine and chemokine responses to Plasmodium falciparum antigens in a highland area of Kenya after a prolonged absence of malaria exposure.在肯尼亚高地地区长时间没有疟疾暴露后，对恶性疟原虫抗原的抗原特异性细胞因子和趋化因子反应的变化。
Infect Immun. 2014 Sep;82(9):3775-82. doi: 10.1128/IAI.01924-14. Epub 2014 Jun 23.
9
Cellular tumor necrosis factor, gamma interferon, and interleukin-6 responses as correlates of immunity and risk of clinical Plasmodium falciparum malaria in children from Papua New Guinea.细胞肿瘤坏死因子、γ干扰素及白细胞介素-6反应与巴布亚新几内亚儿童免疫力及临床恶性疟原虫疟疾风险的相关性
Infect Immun. 2009 Jul;77(7):3033-43. doi: 10.1128/IAI.00211-09. Epub 2009 Apr 20.
10
Impairment of a pregnant woman's acquired ability to limit Plasmodium falciparum by infection with human immunodeficiency virus type-1.孕妇因感染1型人类免疫缺陷病毒而导致后天限制恶性疟原虫能力受损。
Am J Trop Med Hyg. 1996;55(1 Suppl):42-9. doi: 10.4269/ajtmh.1996.55.42.

引用本文的文献

1
Elevation of serum interleukin-1β levels as a potential indicator for malarial infection and severe malaria: a meta-analysis.血清白细胞介素-1β水平升高作为疟疾感染和重症疟疾的潜在指标：一项荟萃分析
Malar J. 2022 Oct 29;21(1):308. doi: 10.1186/s12936-022-04325-0.
2
High level of soluble human leukocyte antigen (HLA)-G at beginning of pregnancy as predictor of risk of malaria during infancy.妊娠早期高水平可溶性人类白细胞抗原（HLA-G）可预测婴儿期疟疾的发病风险。
Sci Rep. 2019 Jun 24;9(1):9160. doi: 10.1038/s41598-019-45688-w.

本文引用的文献

1
Hyperparasitaemia during clinical malaria episodes in infants aged 0-24 months and its association with in utero exposure to Plasmodium falciparum.0至24个月婴儿临床疟疾发作期间的高疟原虫血症及其与子宫内暴露于恶性疟原虫的关联。
BMC Res Notes. 2018 Apr 4;11(1):232. doi: 10.1186/s13104-018-3339-0.
2
Pro- and anti-inflammatory cytokines in children with malaria in Franceville, Gabon.加蓬弗朗斯维尔市患疟疾儿童体内的促炎和抗炎细胞因子
Am J Clin Exp Immunol. 2017 Feb 15;6(2):9-20. eCollection 2017.
3
Interferon- responses to vaccine candidate antigens decrease in the absence of malaria transmission.在没有疟疾传播的情况下，对候选疫苗抗原的干扰素反应会降低。
PeerJ. 2017 Jan 10;5:e2855. doi: 10.7717/peerj.2855. eCollection 2017.
4
Prenatal exposure to Plasmodium falciparum increases frequency and shortens time from birth to first clinical malaria episodes during the first two years of life: prospective birth cohort study.产前暴露于恶性疟原虫会增加频率并缩短出生至两岁期间首次临床疟疾发作的时间：前瞻性出生队列研究。
Malar J. 2016 Jul 22;15(1):379. doi: 10.1186/s12936-016-1417-0.
5
Immunoregulation in human malaria: the challenge of understanding asymptomatic infection.人类疟疾中的免疫调节：理解无症状感染面临的挑战。
Mem Inst Oswaldo Cruz. 2015 Dec;110(8):945-55. doi: 10.1590/0074-02760150241. Epub 2015 Dec 11.
6
Malaria in Pregnancy Interacts with and Alters the Angiogenic Profiles of the Placenta.妊娠期疟疾与胎盘的血管生成特征相互作用并改变其特征。
PLoS Negl Trop Dis. 2015 Jun 19;9(6):e0003824. doi: 10.1371/journal.pntd.0003824. eCollection 2015.
7
Epidemiology of malaria in a village in the Rufiji River Delta, Tanzania: declining transmission over 25 years revealed by different parasitological metrics.坦桑尼亚鲁菲吉河三角洲一个村庄的疟疾流行病学：不同寄生虫学指标显示25年来传播率下降
Malar J. 2014 Nov 26;13:459. doi: 10.1186/1475-2875-13-459.
8
Impact of pregnancy-associated malaria on infant malaria infection in southern Benin.贝宁南部妊娠相关疟疾对婴儿疟疾感染的影响。
PLoS One. 2013 Nov 13;8(11):e80624. doi: 10.1371/journal.pone.0080624. eCollection 2013.
9
Humoral and cellular immunity to Plasmodium falciparum merozoite surface protein 1 and protection from infection with blood-stage parasites.对恶性疟原虫裂殖子表面蛋白 1 的体液和细胞免疫与对血期寄生虫感染的保护作用。
J Infect Dis. 2013 Jul;208(1):149-58. doi: 10.1093/infdis/jit134. Epub 2013 Mar 28.
10
Quantification of the burden and consequences of pregnancy-associated malaria in the Democratic Republic of the Congo.刚果民主共和国妊娠相关疟疾负担和后果的量化。
J Infect Dis. 2011 Dec 1;204(11):1762-71. doi: 10.1093/infdis/jir625. Epub 2011 Oct 11.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验