低、不稳定传播地区高原地区临床疟疾免疫的发展。
Development of clinical immunity to malaria in highland areas of low and unstable transmission.
机构信息
Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA.
出版信息
Am J Trop Med Hyg. 2012 Nov;87(5):806-12. doi: 10.4269/ajtmh.2012.11-0530. Epub 2012 Sep 17.
Abstract
In highland areas of unstable, low malaria transmission, the extent to which immunity to uncomplicated malaria develops with age and intermittent parasite exposure has not been well characterized. We conducted active surveillance for clinical malaria during April 2003-March 2005 in two highland areas of western Kenya (Kapsisiywa and Kipsamoite). In both sites, annual malaria incidence was significantly lower in persons ≥ 15 years of age than in persons < 5 years of age (Kapsisiywa: incidence = 382.9 cases/1,000 persons among persons < 1-4 years of age versus 135.1 cases/1,000 persons among persons ≥ 15 years of age; Kipsamoite: incidence = 233.0 cases/1,000 persons in persons < 1-4 years of age versus 43.3 cases/1,000 persons in persons ≥ 15 years of age). In Kapsisiywa, among persons with malaria, parasite density and axillary body temperature were also significantly lower in persons ≥ 15 years of age than in persons < 5 years of age. Even in highland areas of unstable and low malaria transmission, age is associated with development of clinical immunity to malaria.
摘要
在疟疾不稳定且低传播的高地地区，人们对无并发症疟疾的免疫力随着年龄和间歇性寄生虫暴露而发展的程度尚未得到很好的描述。我们在 2003 年 4 月至 2005 年 3 月期间在肯尼亚西部的两个高地地区（卡普西维瓦和基帕西米特）进行了临床疟疾的主动监测。在这两个地点，≥ 15 岁人群的年疟疾发病率明显低于< 5 岁人群（卡普西维瓦：发病率 = 1-4 岁人群中的 382.9 例/1000 人，而≥ 15 岁人群中的 135.1 例/1000 人；基帕西米特：发病率 = 1-4 岁人群中的 233.0 例/1000 人，而≥ 15 岁人群中的 43.3 例/1000 人）。在卡普西维瓦，在患有疟疾的人群中，≥ 15 岁人群的寄生虫密度和腋窝体温也明显低于< 5 岁人群。即使在疟疾不稳定且低传播的高地地区，年龄也与对疟疾的临床免疫力的发展有关。
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