Mahaley M S, Dropcho E J, Bertsch L, Tirey T, Gillespie G Y
Division of Neurological Surgery, University of Alabama, Birmingham.
J Neurosurg. 1989 Nov;71(5 Pt 1):639-41. doi: 10.3171/jns.1989.71.5.0639.
Recombinant beta-interferon in escalating dosages was administered intravenously three times weekly to seven patients with recurrent gliomas. No evidence of response was seen in any patient, either on neurological examination or by computerized tomography (CT). However, stabilization of tumor volume, assessed from contrast-enhanced CT scans, occurred for 8 to 26 weeks in three patients. Immediate progression of disease despite treatment occurred in four patients.
对7例复发性神经胶质瘤患者每周3次静脉注射递增剂量的重组β-干扰素。无论是神经系统检查还是计算机断层扫描（CT），均未发现任何患者有反应的证据。然而，根据增强CT扫描评估，3例患者的肿瘤体积稳定了8至26周。4例患者尽管接受了治疗，但疾病仍立即进展。
