Mahaley M S, Bertsch L, Cush S, Gillespie G Y
Division of Neurological Surgery, University of Alabama, Birmingham.
J Neurosurg. 1988 Dec;69(6):826-9. doi: 10.3171/jns.1988.69.6.0826.
Recombinant gamma-interferon (2 mg/sq m) was administered intravenously twice weekly in 8-week courses to 14 patients with recurrent gliomas. Computerized tomography (CT) evidence of response was seen in only one patient, and stabilization for 12 to 86 weeks was recorded in three. This was a disappointing result, particularly in a series of patients with relatively small initial tumor volumes (less than 50 cu mm on enhanced CT) and Karnofsky functional ratings of 70 or higher. In addition, several instances of toxicity potentially attributable to gamma-interferon were observed.
对14例复发性神经胶质瘤患者，每周两次静脉注射重组γ干扰素（2毫克/平方米），疗程为8周。仅1例患者经计算机断层扫描（CT）显示有反应，3例患者病情稳定达12至86周。这一结果令人失望，尤其是对一系列初始肿瘤体积相对较小（增强CT显示小于50立方毫米）且卡诺夫斯基功能评分在70分及以上的患者。此外，还观察到几例可能归因于γ干扰素的毒性反应。
