Hiwatashi Akio, Togao Osamu, Yamashita Koji, Kikuchi Kazufumi, Yoshikawa Hiroshi, Obara Makoto, Honda Hiroshi
Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, 812-8582, Fukuoka, Japan.
Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, 812-8582, Fukuoka, Japan.
Clin Neuroradiol. 2018 Jun;28(2):261-266. doi: 10.1007/s00062-016-0556-6. Epub 2017 Jan 17.
To differentiate cystic from solid solitary intraorbital tumors using 3D turbo field echo with diffusion-sensitized driven-equilibrium preparation without contrast material.
This retrospective study was approved by our institutional review boards, and written informed consent was waived. A total of 26 patients with intraorbital tumors were studied. Motion probing gradients were conducted at one direction with b‑values of 0 and 500 s/mm. The voxel size was 1.5 × 1.5 × 1.5 mm, and acquisition time was 5 min 22 s. Additionally, fat-suppressed T2-weighted imaging (T2WI) and T1WI were obtained. The apparent diffusion coefficients (ADC) of the lesions were measured. Signal intensity on conventional magnetic resonance imaging (MRI) compared to normal appearing white matter was also measured. Statistical analysis was performed with Mann-Whitney U-test, the Steel-Dwass test and the receiver operating characteristic (ROC) analysis.
There were 10 cystic (7 dermoids, 2 epidermoids, and 1 cystadenoma) and 16 solid (8 cavernous hemangiomas, 6 pleomorphic adenomas, 1 adenocarcinoma, and 1 sebaceous carcinoma) tumors. The ADC of the cystic tumors (mean ± SD; 2.21 ± 0.76 × 10 mm/s) was statistically significantly lower than that of solid tumors (1.43 ± 0.41 × 10 mm/s; P < 0.05).; however, there were no statistically significant differences on conventional MRI (P > 0.05). There were no statistically significant differences among tumor subtypes in all parameters (P > 0.05). The ROC analysis showed the best diagnostic performance with ADC (Az = 0.77).
With its insensitivity to field inhomogeneity and high spatial resolution, the 3D DSDE-TFE technique enabled us to discriminate cystic tumors from solid tumors.
使用无对比剂的三维涡轮场回波与扩散敏感驱动平衡准备技术区分眼眶内囊性和实性孤立性肿瘤。
本回顾性研究经机构审查委员会批准，且无需书面知情同意。共研究了26例眼眶内肿瘤患者。在一个方向上进行运动探测梯度，b值为0和500 s/mm²。体素大小为1.5×1.5×1.5 mm，采集时间为5分22秒。此外，还获得了脂肪抑制T2加权成像（T2WI）和T1WI。测量病变的表观扩散系数（ADC）。还测量了常规磁共振成像（MRI）上与正常白质相比的信号强度。采用曼-惠特尼U检验、Steel-Dwass检验和受试者操作特征（ROC）分析进行统计分析。
有10例囊性肿瘤（7例皮样囊肿、2例表皮样囊肿和1例囊腺瘤）和16例实性肿瘤（8例海绵状血管瘤、6例多形性腺瘤、1例腺癌和1例皮脂腺癌）。囊性肿瘤的ADC（平均值±标准差；2.21±0.76×10⁻³mm²/s）在统计学上显著低于实性肿瘤（1.43±0.41×10⁻³mm²/s；P<0.05）；然而，常规MRI上无统计学显著差异（P>0.05）。所有参数在肿瘤亚型之间均无统计学显著差异（P>0.05）。ROC分析显示ADC的诊断性能最佳（Az=0.77）。
三维扩散敏感驱动平衡涡轮场回波（3D DSDE-TFE）技术对场不均匀性不敏感且空间分辨率高，使我们能够区分囊性肿瘤和实性肿瘤。
