Hiwatashi A, Yoshiura T, Togao O, Yamashita K, Kikuchi K, Kobayashi K, Ohga M, Sonoda S, Honda H, Obara M
Departments of Clinical Radiology.
AJNR Am J Neuroradiol. 2014 Jan;35(1):95-8. doi: 10.3174/ajnr.A3620. Epub 2013 Jul 18.
3D turbo field echo with diffusion-sensitized driven-equilibrium preparation is a non-echo-planar technique for DWI, which enables high-resolution DWI without field inhomogeneity-related image distortion. The purpose of this study was to evaluate the feasibility of diffusion-sensitized driven-equilibrium turbo field echo in evaluating diffusivity in the normal pituitary gland.
First, validation of diffusion-sensitized driven-equilibrium turbo field echo was attempted by comparing it with echo-planar DWI. Five healthy volunteers were imaged by using diffusion-sensitized driven-equilibrium turbo field echo and echo-planar DWI. The imaging voxel size was 1.5 × 1.5 × 1.5 mm(3) for diffusion-sensitized driven-equilibrium turbo field echo and 1.5 × 1.9 × 3.0 mm(3) for echo-planar DWI. ADCs measured by the 2 methods in 15 regions of interests (6 in gray matter and 9 in white matter) were compared by using the Pearson correlation coefficient. The ADC in the pituitary anterior lobe was then measured in 10 volunteers by using diffusion-sensitized driven-equilibrium turbo field echo, and the results were compared with those in the pons and vermis by using a paired t test.
The ADCs from the 2 methods showed a strong correlation (r = 0.79; P < .0001), confirming the accuracy of the ADC measurement with the diffusion-sensitized driven-equilibrium sequence. The ADCs in the normal pituitary gland were 1.37 ± 0.13 × 10(-3) mm(2)/s, which were significantly higher than those in the pons (1.01 ± 0.24 × 10(-3) mm(2)/s) and the vermis (0.89 ± 0.25 × 10(-3) mm(2)/s, P < .01).
We demonstrated that diffusion-sensitized driven-equilibrium turbo field echo is feasible in assessing ADC in the pituitary gland.
具有扩散敏感驱动平衡准备的三维快速场回波是一种用于扩散加权成像（DWI）的非回波平面技术，它能够实现高分辨率DWI且无磁场不均匀性相关的图像失真。本研究的目的是评估扩散敏感驱动平衡快速场回波在评估正常垂体腺扩散率方面的可行性。
首先，通过将扩散敏感驱动平衡快速场回波与回波平面DWI进行比较，尝试对其进行验证。5名健康志愿者接受了扩散敏感驱动平衡快速场回波和回波平面DWI成像。扩散敏感驱动平衡快速场回波的成像体素大小为1.5×1.5×1.5mm³，回波平面DWI的成像体素大小为1.5×1.9×3.0mm³。采用Pearson相关系数比较两种方法在15个感兴趣区域（6个在灰质，9个在白质）测量的表观扩散系数（ADC）。然后，使用扩散敏感驱动平衡快速场回波对10名志愿者的垂体前叶ADC进行测量，并采用配对t检验将结果与脑桥和小脑蚓部的结果进行比较。
两种方法测得的ADC显示出很强的相关性（r = 0.79；P <.0001），证实了扩散敏感驱动平衡序列测量ADC的准确性。正常垂体腺的ADC为1.37±0.13×10⁻³mm²/s，显著高于脑桥（1.01±0.24×10⁻³mm²/s）和小脑蚓部（0.89±0.25×10⁻³mm²/s，P <.01）。
我们证明了扩散敏感驱动平衡快速场回波在评估垂体腺ADC方面是可行的。
