水合甘氨酸的结构：对甘氨酸从溶液中结晶及其在太空中结构的影响。
The Structure of Glycine Dihydrate: Implications for the Crystallization of Glycine from Solution and Its Structure in Outer Space.
机构信息
X-ray Science Division, Advanced Photon Source, Argonne National Laboratory, Argonne, IL, 60439, USA.
Department of Physics and Astronomy, High Pressure Science and Engineering Center, University of Nevada Las Vegas, Las Vegas, NV, 89154, USA.
出版信息
Angew Chem Int Ed Engl. 2017 Feb 13;56(8):2030-2034. doi: 10.1002/anie.201610977. Epub 2017 Jan 18.
Glycine, the simplest amino acid, is also the most polymorphous. Herein, we report the structure determination of a long unknown phase of glycine, which was first reported by Pyne and Suryanarayanan in 2001. To date, this phase has only been prepared at 208 K as nanocrystals within ice. Through computational crystal-structure prediction and powder X-ray diffraction methods, we identified this elusive phase as glycine dihydrate (GDH), representing the first report on the structure of a hydrated glycine structure. The structure of GDH has important implications for the state of glycine in aqueous solution and the mechanisms of glycine crystallization. GDH may also be the form of glycine that comes to Earth from extraterrestrial sources.
甘氨酸是最简单的氨基酸，也是多晶型性最强的氨基酸。在此，我们报告了甘氨酸一个长期未知相的结构确定，该相于 2001 年首次由 Pyne 和 Suryanarayanan 报道。迄今为止，该相仅在 208 K 下以冰中的纳米晶体形式制备。通过计算晶体结构预测和粉末 X 射线衍射方法，我们将这种难以捉摸的相鉴定为甘氨酸二水合物（GDH），这是首次报道甘氨酸水合物结构。GDH 的结构对甘氨酸在水溶液中的状态和甘氨酸结晶机制具有重要意义。GDH 也可能是来自外星的甘氨酸形式。
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