State Key Laboratory of Medical Genomics, Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Chinese Clinical Research Center for Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Department of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
J Diabetes. 2018 Jun;10(6):442-448. doi: 10.1111/1753-0407.12531. Epub 2017 Mar 29.
Bisphenol A (BPA) exposure has been associated with diabetes and related metabolic disorders, such as obesity, but studies of the association of urinary BPA concentrations with central obesity risk are limited. The aim of this study was to prospectively investigate the association between urinary BPA and incident central obesity in a Chinese population aged ≥40 years.
The study followed 888 participants from Shanghai, China, who did not have central obesity at baseline (in 2009) for 4 years. Concentrations of BPA were measured in baseline morning spot urine samples. Central obesity was defined as waist circumference ≥90 cm in men and ≥80 cm in women.
During a mean follow-up of 4 years, 124 (14.0%) participants developed central obesity. Each 1-unit increase in log [BPA] was positively associated with a 2.30-fold risk of incident central obesity (95% confidence interval [CI] 1.39-3.78; P < 0.001) after adjustment for confounders. Compared with the lowest tertile of urinary BPA concentration, Tertiles 2 and 3 were associated with a higher risk of incident central obesity (odds ratios 1.73 [95% CI 1.04-2.88] and 1.81 [95% CI 1.08-3.05], respectively). Stratified analysis showed significant associations of BPA with incident central obesity in women and individuals <60 years of age, with normal weight, non-smokers, non-drinkers, or non-hypertensives.
The results indicate that higher urinary BPA concentrations may be associated with a greater risk of incident central obesity in Chinese adults. The study emphasizes the effects of BPA exposure on metabolic risk from a public health perspective.
双酚 A（BPA）暴露与糖尿病和相关代谢紊乱有关，如肥胖，但关于尿 BPA 浓度与中心性肥胖风险的研究有限。本研究旨在前瞻性调查中国≥40 岁人群中尿 BPA 与中心性肥胖发病的关系。
本研究对 888 名来自中国上海的参与者进行了随访，这些参与者在基线（2009 年）时没有中心性肥胖，随访时间为 4 年。在基线晨时尿样中测量 BPA 浓度。中心性肥胖定义为男性腰围≥90cm，女性腰围≥80cm。
在平均 4 年的随访期间，124 名（14.0%）参与者发生了中心性肥胖。在调整混杂因素后，log[BPA]每增加 1 个单位，中心性肥胖发病的风险增加 2.30 倍（95%置信区间 1.39-3.78；P<0.001）。与尿 BPA 浓度最低三分位相比，第二和第三分位与中心性肥胖发病风险增加相关（比值比 1.73 [95%置信区间 1.04-2.88]和 1.81 [95%置信区间 1.08-3.05]）。分层分析显示，BPA 与女性和年龄<60 岁、体重正常、不吸烟、不饮酒或无高血压的人群中心性肥胖发病显著相关。
研究结果表明，较高的尿 BPA 浓度可能与中国成年人中心性肥胖发病风险增加相关。该研究从公共卫生角度强调了 BPA 暴露对代谢风险的影响。
