Dias Juliana, Axelband Flavia, Lara Lucienne S, Muzi-Filho Humberto, Vieyra Adalberto
1 National Institute of Cancer, Rio de Janeiro, Brazil.
2 Carlos Chagas Institute of Biophysics, Federal University of Rio de Janeiro, Brazil.
J Renin Angiotensin Aldosterone Syst. 2017 Jan;18(1):1470320316689338. doi: 10.1177/1470320316689338.
Angiotensin-(3-4) (Ang-(3-4) or Val-Tyr) is the shorter angiotensin (Ang) II-derived peptide, formed through successive hydrolysis that culminates with the release of Val-Tyr as a dipeptide. It is formed both in plasma and in kidney from Ang II and Ang III, and can be considered a component of the systemic and organ-based renin-angiotensin system. It is potently antihypertensive in humans and rats, and its concerted actions on proximal tubule cells culminate in the inhibition of fluid reabsorption, hyperosmotic urinary excretion of Na. At the renal cell signaling level, Ang-(3-4) counteracts Ang II-type 1 receptor-mediated responses by acting as an allosteric enhancer in Ang II-type 2 receptor populations that target adenosine triphosphate-dependent Ca and Na transporters through a cyclic adenosine monophosphate-activated protein kinase pathway.
血管紧张素 -（3 - 4）（Ang -（3 - 4）或缬氨酸 - 酪氨酸）是较短的源自血管紧张素（Ang）II的肽，通过连续水解形成，最终释放出二肽缬氨酸 - 酪氨酸。它在血浆和肾脏中由Ang II和Ang III形成，可被视为全身和基于器官的肾素 - 血管紧张素系统的一个组成部分。它在人类和大鼠中具有强大的降压作用，其对近端小管细胞的协同作用最终导致液体重吸收受到抑制，钠的高渗性尿排泄。在肾细胞信号传导水平，Ang -（3 - 4）通过在靶向三磷酸腺苷依赖性钙和钠转运体的Ang II 2型受体群体中作为变构增强剂，通过环磷酸腺苷激活的蛋白激酶途径来抵消Ang II 1型受体介导的反应。
