治疗前血小板增多症可能预测结直肠癌患者的预后：一项系统评价和荟萃分析。

The pretreatment thrombocytosis may predict prognosis of patients with colorectal cancer: a systematic review and meta-analysis.

作者信息

Wang Yong-Hong, Deng Shao-Jun, Yang Yong-Dong, Yao Nan, Zhao Jian-Meng, Min Guang-Tao, Wang Jun, Xu Teng-Fei, Zhao Peng-Ying, Wang Hong-Peng, Chen Wei

机构信息

Department of General Surgery, The First People's Hospital of Xi'ning City, Xi'ning 810000, Qinghai Province, PR China.

Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, PR China.

出版信息

Biomark Med. 2017 Feb;11(2):195-210. doi: 10.2217/bmm-2016-0214. Epub 2017 Jan 18.

DOI:10.2217/bmm-2016-0214

PMID:28097884

Abstract

AIM

Recently, several studies have reported that thrombocytosis may be associated with the poor prognosis of colorectal cancer (CRC). Nevertheless, their conclusions were still controversial. Results & methodology: We searched PubMed, Embase, Cochrane Library and Web of Science up to April 2016. A total of 30 studies including 9129 patients were included in this meta-analysis. Thrombocytosis had a close relationship with the poor overall survival of CRC compared with normal platelet counts, with the pooled hazard ratios being 1.89 (95% CI: 1.45-2.47; p < 0.00001) and 1.83 (95% CI: 1.33-2.53; p = 0.0002), with univariate and multivariate analyses, respectively.

DISCUSSION & CONCLUSION: This meta-analysis indicated that thrombocytosis may be a cost-effective and noninvasive indicator for poor prognosis of patients with CRC, especially for overall survival.

摘要

目的

最近，多项研究报告称血小板增多症可能与结直肠癌（CRC）的不良预后相关。然而，它们的结论仍存在争议。结果与方法：我们检索了截至2016年4月的PubMed、Embase、Cochrane图书馆和科学网。本荟萃分析共纳入30项研究，包括9129例患者。与正常血小板计数相比，血小板增多症与CRC患者较差的总生存率密切相关，单因素和多因素分析的合并风险比分别为1.89（95%CI：1.45 - 2.47；p < 0.00001）和1.83（95%CI：1.33 - 2.53；p = 0.0002）。