Kawano Hiroki, Sonoda Shozo, Saito Shiro, Terasaki Hiroto, Sakamoto Taiji
Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Retina. 2017 Nov;37(11):2175-2182. doi: 10.1097/IAE.0000000000001465.
To compare the structural characteristics of the choroid in the areas with greater retinal degeneration to the areas with less retinal degeneration in eyes with retinitis pigmentosa (RP).
Patients with RP who had a hyperautofluorescent ring were studied. The choroidal images obtained by enhanced depth imaging optical coherence tomography located 7,500 μm from the optic disk in the horizontal plane were analyzed. The cross-sectional areas of the total, luminal, and stromal choroid were measured. The area within the hyperautofluorescent ring was defined as the "central choroid" with less retinal degeneration.
Thirty-seven eyes of 24 patients with RP were studied. The cross-sectional area of the total choroid was significantly smaller in the RP eyes than that in the control eyes (P < 0.01). The stromal areas of the choroid were not significantly different from the stromal areas of the controls. However, the luminal areas of the nasal and temporal choroid in the RP eyes were significantly smaller than that of the corresponding areas of the controls. The ratio of the luminal area to the total choroidal area in the central choroid was 68.0 ± 3.3% which was significantly larger than that of the nasal or the temporal choroid (P < 0.01).
The choroidal structure is differentially altered in eyes with RP. The changes in the choroid were dependent on whether they were located within the hyperautofluorescent or outside the hyperautofluorescent ring.
比较视网膜色素变性（RP）患者中视网膜变性程度较重区域与较轻区域的脉络膜结构特征。
对患有高自发荧光环的RP患者进行研究。分析通过增强深度成像光学相干断层扫描在水平面上距视盘7500μm处获得的脉络膜图像。测量总脉络膜、管腔脉络膜和脉络膜基质的横截面积。将高自发荧光环内的区域定义为视网膜变性较轻的“中央脉络膜”。
对24例RP患者的37只眼进行了研究。RP患者眼中总脉络膜的横截面积显著小于对照眼（P < 0.01）。脉络膜基质面积与对照眼的基质面积无显著差异。然而，RP患者眼中鼻侧和颞侧脉络膜的管腔面积显著小于对照眼相应区域的管腔面积。中央脉络膜管腔面积与总脉络膜面积之比为6８.0 ± 3.3%，显著大于鼻侧或颞侧脉络膜（P < 0.01）。
RP患者眼中脉络膜结构存在差异改变。脉络膜的变化取决于其位于高自发荧光环内还是环外。
