Department of Ophthalmology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
Japan Clinical Retina Study Group (J-CREST Group), Kagoshima, Japan.
Retina. 2019 Dec;39(12):2399-2409. doi: 10.1097/IAE.0000000000002285.
To investigate the choroidal structures in the enhanced depth imaging optical coherence tomographic images in eyes with retinitis pigmentosa (RP) and to determine correlations between the choroidal structures and visual functions.
The enhanced depth imaging optical coherence tomographic images of 100 eyes with typical RP and 60 age-, sex-, and axial length-matched normal eyes were binarized using ImageJ. The cross-sectional luminal and stromal areas of the inner and outer subfoveal choroid of 1,500-µm width were measured. The inner choroid included the choriocapillaris and medium vessel layer, and the outer choroid included the larger vessel layer.
In the inner choroid, the luminal area and the ratio of luminal/total choroidal area (L/C ratio) were significantly smaller in RP than in controls (P = 0.010, P < 0.001, respectively), whereas the stromal area was not significantly different (P = 0.114). The inner choroidal L/C ratio was significantly correlated with the best-corrected visual acuity, mean deviation, foveal sensitivity, width of the ellipsoid zone, and central foveal thickness in RP after adjusting for the axial length, age, and sex (all P < 0.005).
The significant correlations between the inner choroidal structures and the visual functions and retinal structures indicate that the choroidal structures are altered in association with the progression of RP.
研究色素性视网膜炎（RP）患者增强深度成像光相干断层扫描图像中的脉络膜结构，并确定脉络膜结构与视觉功能之间的相关性。
使用 ImageJ 对 100 只典型 RP 眼和 60 只年龄、性别和眼轴长度匹配的正常眼的增强深度成像光相干断层扫描图像进行二值化处理。测量 1500µm 宽度的内、外鼻下脉络膜的横截面积。内脉络膜包括脉络膜毛细血管和中血管层，外脉络膜包括大血管层。
在内脉络膜中，RP 眼的管腔面积和管腔/总脉络膜面积比（L/C 比）明显小于对照组（P=0.010，P<0.001），而脉络膜基质面积无明显差异（P=0.114）。在内脉络膜中，L/C 比与 RP 眼的最佳矫正视力、平均偏差、中心凹敏感度、椭圆体带宽度和中心凹厚度显著相关，校正眼轴、年龄和性别后均有统计学意义（均 P<0.005）。
内脉络膜结构与视觉功能和视网膜结构之间的显著相关性表明，脉络膜结构与 RP 的进展有关。
