Saetang Jirakrit, Sangkhathat Surasak
Department of Biomedical Sciences, Faculty of Medicine, Prince of Songkla University, Songkhla 90110, Thailand.
Tumor Biology Research Unit, Department of Surgery, Faculty of Medicine, Prince of Songkla University, Songkhla 90110, Thailand.
Oncol Rep. 2017 Mar;37(3):1312-1320. doi: 10.3892/or.2017.5385. Epub 2017 Jan 18.
Diets have been believed to be an important factor in the development of metabolic syndrome and colorectal cancer (CRC). In recent years, many studies have shown an intimate relationship between mucosal immunity, metabolism and diets, which has led to a greater understanding of the pathophysiology of metabolic syndrome and CRC development. Although the precise effects of diets on oncogenesis have not been compl-etely elucidated, microbiota changes and inflammation are believed to be important factors that influence the development of CRC. Moreover, increased release of pro-inflammatory cytokines and alteration of adipokine levels have been observed in patients with colorectal adenoma and/or CRC, and these all have been considered as the important mechanisms that link diets to the development of metabolic syndrome and CRC. Importantly, a high-fat, low-fiber diet is associated with dysbiosis, and as the gut signature becomes more important in metabolic syndrome and CRC, an increased understanding of diets on bacterial activity in the pathogenesis of metabolic syndrome and CRC will lead to new preventive and therapeutic strategies.
饮食被认为是代谢综合征和结直肠癌（CRC）发生发展的一个重要因素。近年来，许多研究表明黏膜免疫、代谢与饮食之间存在密切关系，这使得人们对代谢综合征和CRC发生发展的病理生理学有了更深入的了解。尽管饮食对肿瘤发生的确切影响尚未完全阐明，但微生物群变化和炎症被认为是影响CRC发生发展的重要因素。此外，在结直肠腺瘤和/或CRC患者中观察到促炎细胞因子释放增加和脂肪因子水平改变，这些都被视为将饮食与代谢综合征和CRC发生发展联系起来的重要机制。重要的是，高脂肪、低纤维饮食与微生物群失调有关，随着肠道特征在代谢综合征和CRC中变得越来越重要，深入了解饮食对代谢综合征和CRC发病机制中细菌活性的影响将带来新的预防和治疗策略。
