Pan Shuang, Hong Wandong, Wu Wenzhi, Chen Qinfen, Zhao Qian, Wu Jiansheng, Jin Yin
Department of Gastroenterology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China.
Medicine (Baltimore). 2017 Jan;96(2):e5809. doi: 10.1097/MD.0000000000005809.
Colorectal neoplasm is considered to have a strong association with nonalcoholic fatty liver disease (NAFLD) and metabolic syndrome (MetS), respectively. The relationship among NAFLD, MetS, and colorectal neoplasm was assessed in 1793 participants. Participants were divided into 4 groups based on the status of NAFLD and MetS. Relative excess risks of interaction (RERI), attributable proportion (AP), and synergy index (SI) were applied to evaluate the additive interaction. NAFLD and MetS were significantly correlated with colorectal neoplasm and colorectal cancer (CRC), respectively. The incidence of CRC in NAFLD (+) MetS (+) group was significantly higher than other 3 groups. The result of RERI, AP, and SI indicated the significant additive interaction of NAFLD and MetS on the development of CRC. NAFLD and MetS are risk factors for colorectal neoplasm and CRC, respectively. And NAFLD and MetS have an additive effect on the development of CRC.
结直肠肿瘤被认为分别与非酒精性脂肪性肝病（NAFLD）和代谢综合征（MetS）密切相关。在1793名参与者中评估了NAFLD、MetS和结直肠肿瘤之间的关系。参与者根据NAFLD和MetS的状况分为4组。采用交互作用的相对超额风险（RERI）、归因比例（AP）和协同指数（SI）来评估相加交互作用。NAFLD和MetS分别与结直肠肿瘤和结直肠癌（CRC）显著相关。NAFLD（+）MetS（+）组的CRC发病率显著高于其他3组。RERI、AP和SI的结果表明NAFLD和MetS在CRC发生发展中存在显著的相加交互作用。NAFLD和MetS分别是结直肠肿瘤和CRC的危险因素。并且NAFLD和MetS在CRC发生发展中具有相加作用。
