Huang Dan, Shin Woo-Kyoung, De la Torre Katherine, Lee Hwi-Won, Min Sukhong, Shin Aesun, Lee Jong-Koo, Kang Daehee
Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea.
Integrated Major in Innovative Medical Science, Seoul National University Graduate School, Seoul, South Korea.
Gastric Cancer. 2023 Jul;26(4):481-492. doi: 10.1007/s10120-023-01382-5. Epub 2023 Apr 3.
Previous studies suggested that metabolic syndrome (MetS) might create a pro-cancer environment and increase cancer incidence. However, evidence on the risk of gastric cancer (GC) was limited. This study aimed to evaluate the association between MetS and its components and GC in the Korean population.
Included were 108,397 individuals who participated in the large-scale prospective cohort study, the Health Examinees-Gem study during 2004-2017. The multivariable Cox proportional was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) on the association between MetS and its components with GC risk. Age was used as the time scale in the analyses. The stratified analysis was performed to determine the joint effect of lifestyle factors and MetS on GC risk in different groups.
During the mean follow-up of 9.1 years, 759 cases of newly diagnosed cancer (408 men and 351 women) were identified. Overall, participants with MetS had a 26% increased risk of GC than those without MetS (HR 1.26; 95% CI 1.07-1.47); the risk increased with the number of MetS components (p for trend 0.01). Hypertriglyceridemia, low HDL-cholesterol, and hyperglycemia were independently associated with the risk of GC. The potential joint effect of MetS and current smokers (p for interaction 0.02) and obesity (BMI ≥ 25.0) (p for interaction 0.03) in GC.
In this prospective cohort study, we found that MetS were associated with an increased risk of GC in the Korean population. Our findings suggest that MetS may be a potentially modifiable risk factor for GC risk.
先前的研究表明，代谢综合征（MetS）可能会营造促癌环境并增加癌症发病率。然而，关于胃癌（GC）风险的证据有限。本研究旨在评估韩国人群中MetS及其组分与GC之间的关联。
纳入了108,397名参与2004年至2017年期间大规模前瞻性队列研究即健康体检者-宝石研究的个体。采用多变量Cox比例风险模型来估计MetS及其组分与GC风险之间关联的风险比（HRs）和95%置信区间（CIs）。分析中以年龄作为时间尺度。进行分层分析以确定生活方式因素和MetS对不同组GC风险的联合效应。
在平均9.1年的随访期间，共确诊759例新发癌症（男性408例，女性351例）。总体而言，患有MetS的参与者患GC的风险比未患MetS的参与者高26%（HR 1.26；95% CI 1.07 - 1.47）；风险随MetS组分数量的增加而升高（趋势p值为0.01）。高甘油三酯血症、低高密度脂蛋白胆固醇血症和高血糖与GC风险独立相关。MetS与当前吸烟者（交互作用p值为0.02）以及肥胖（BMI≥25.0）（交互作用p值为0.03）在GC方面存在潜在的联合效应。
在这项前瞻性队列研究中，我们发现MetS与韩国人群中GC风险增加相关。我们的研究结果表明，MetS可能是GC风险的一个潜在可改变的风险因素。
