Bernardes Danielle, de Oliveira Alexandre Leite Rodrigues
Laboratory of Nerve Regeneration, Department of Structural and Functional Biology, Institute of Biology, University of Campinas, Campinas, Brazil.
Front Neurol. 2018 Nov 20;9:950. doi: 10.3389/fneur.2018.00950. eCollection 2018.
Although it has been suggested that healthier lifestyle may optimize effects of the immunomodulation drugs for treating multiple sclerosis (MS), the knowledge regarding this kind of interactions is limited. The aim of the present study was to investigate the effects of treadmill exercise in combination with pharmacological treatment in an animal model for MS. C57BL/6J female mice were subjected to daily treadmill exercise for 4 weeks before immunization and 6 weeks before clinical presentation of disease. Dimethyl fumarate (DMF) or glatiramer acetate (GA) were administered after the first clinical relapse. Histopathological analyses were carried out in the lumbar spinal cord at peak disease and at 1 or 14 days post-treatment (dpt). Exercised-GA treated animals demonstrated decreased astrocytic response in the spinal dorsal horn with an improvement in the paw print pressure. Exercised-DMF treated animals showed an increased microglial/macrophage response on both ventral and dorsal horn that were associated with clinical improvement and synaptic motoneuron inputs density. The present data suggest that prior regular exercise can modify the effects of pharmacological treatment administered after the first relapse in a murine model for MS.
尽管有人提出更健康的生活方式可能会优化免疫调节药物治疗多发性硬化症（MS）的效果，但关于这类相互作用的知识有限。本研究的目的是在MS动物模型中研究跑步机运动联合药物治疗的效果。C57BL/6J雌性小鼠在免疫前每天进行4周的跑步机运动，并在疾病临床表现前6周进行运动。在首次临床复发后给予富马酸二甲酯（DMF）或醋酸格拉替雷（GA）。在疾病高峰期以及治疗后1天或14天（dpt）对腰脊髓进行组织病理学分析。运动加GA治疗的动物脊髓背角星形细胞反应降低，爪印压力改善。运动加DMF治疗的动物在腹角和背角的小胶质细胞/巨噬细胞反应增加，这与临床改善以及突触运动神经元输入密度有关。目前的数据表明，在MS小鼠模型中，首次复发后进行规律运动可以改变药物治疗的效果。
