Satb1: 抑制 PD1 和 T 细胞耗竭。
Satb1: Restraining PD1 and T Cell Exhaustion.
机构信息
Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Graduate Program in Immunology and Microbial Pathogenesis, Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY 10065, USA.
Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Graduate Program in Immunology and Microbial Pathogenesis, Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY 10065, USA.
出版信息
Immunity. 2017 Jan 17;46(1):3-5. doi: 10.1016/j.immuni.2017.01.002.
Mechanisms that govern PD1 expression and exhaustion in T cells are not fully understood. In this issue of Immunity, Stephen et al. (2017) uncover a key role for the genome organizer Satb1 in restraining PD1 expression and promoting tumor immunity.
PD1 在 T 细胞中的表达和耗竭的调控机制尚不完全清楚。在本期《免疫》杂志上，Stephen 等人（2017）揭示了基因组组织者 Satb1 在抑制 PD1 表达和促进肿瘤免疫方面的关键作用。
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