Yang Wen-Qi, Li Hong
Pediatric Center, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2017 Jan;19(1):126-129. doi: 10.7499/j.issn.1008-8830.2017.01.021.
The time phase of epileptic seizures has attracted more and more attention. Epileptic seizures have their own circadian rhythm. The same type of epilepsy has different seizure frequencies in different time periods and states (such as sleeping/awakening state and natural day/night cycle). The circadian rhythm of epileptic seizures has complex molecular and endocrine mechanisms, and currently there are several hypotheses. Clarification of the circadian rhythm of epileptic seizures and prevention and administration according to such circadian rhythm can effectively control seizures and reduce the adverse effects of drugs. The research on the circadian rhythm of epileptic seizures provides a new idea for the treatment of epilepsy.
癫痫发作的时间阶段已越来越受到关注。癫痫发作有其自身的昼夜节律。同一类型的癫痫在不同时间段和状态（如睡眠/觉醒状态以及自然的白天/黑夜周期）下具有不同的发作频率。癫痫发作的昼夜节律具有复杂的分子和内分泌机制，目前有几种假说。阐明癫痫发作的昼夜节律并根据这种昼夜节律进行预防和给药可有效控制发作并减少药物的不良反应。对癫痫发作昼夜节律的研究为癫痫治疗提供了新思路。
