早期帕金森病患者肠道乙酰胆碱酯酶减少：一项多奈哌齐PET研究。
Decreased intestinal acetylcholinesterase in early Parkinson disease: An C-donepezil PET study.
作者信息
Fedorova Tatyana D, Seidelin Louise B, Knudsen Karoline, Schacht Anna C, Geday Jacob, Pavese Nicola, Brooks David J, Borghammer Per
机构信息
From the Department of Nuclear Medicine and PET-Centre (T.D.F., L.B.S., K.K., A.C.S., N.P., D.J.B., P.B.) and Department of Neurology (J.G.), Aarhus University Hospital, Denmark.
出版信息
Neurology. 2017 Feb 21;88(8):775-781. doi: 10.1212/WNL.0000000000003633. Epub 2017 Jan 18.
OBJECTIVE
To investigate systemic levels of acetylcholinesterase in early Parkinson disease (PD) with C-donepezil PET, a potential marker of parasympathetic innervation.
METHODS
This was a cross-sectional study with 19 patients with early-stage PD (disease duration 1.5 ± 0.6 years) and 16 age-matched controls who had clinical assessments, olfaction tests, and C-donepezil PET to measure acetylcholinesterase density in peripheral organs.
RESULTS
The patients with PD showed significantly reduced C-donepezil uptake in the small intestine (-14%, = 0.018), colon (-22%, < 0.001), and kidneys (-14%, = 0.028). No difference in myocardial or pancreatic acetylcholinesterase levels was seen.
CONCLUSION
We found significantly decreased C-donepezil signal in the intestine and kidneys of patients with early PD, suggesting that parasympathetic denervation is present early in the disease course.
目的
使用C-多奈哌齐PET研究早期帕金森病（PD）患者体内乙酰胆碱酯酶的全身水平，这是副交感神经支配的一个潜在标志物。
方法
这是一项横断面研究，纳入了19例早期PD患者（病程1.5±0.6年）和16例年龄匹配的对照者，对他们进行了临床评估、嗅觉测试以及C-多奈哌齐PET检查，以测量外周器官中的乙酰胆碱酯酶密度。
结果
PD患者的小肠（-14%，P = 0.018）、结肠（-22%，P < 0.001）和肾脏（-14%，P = 0.028）中C-多奈哌齐摄取显著降低。心肌或胰腺乙酰胆碱酯酶水平未见差异。
结论
我们发现早期PD患者肠道和肾脏中的C-多奈哌齐信号显著降低，提示在疾病病程早期即存在副交感神经去神经支配。
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