帕金森病患者的肠道屏障有多渗漏？

How leaky is the gut in Parkinson's disease?

作者信息

Derkinderen Pascal, Cossais François, Kulcsárová Kristína, Škorvánek Matej, Sellier-Montaigne Loïc, Coron Emmanuel, Leclair-Visonneau Laurène, Cerri Silvia, Pellegrini Carolina, Rolli-Derkinderen Malvyne

机构信息

Nantes Université, CHU Nantes, INSERM, The Enteric Nervous System in Gut and Brain Disorders, Nantes F-44000, France.

Department of Anatomy, Kiel University, Germany.

出版信息

EBioMedicine. 2025 Jun 3;117:105796. doi: 10.1016/j.ebiom.2025.105796.

DOI:10.1016/j.ebiom.2025.105796

PMID:40466436

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12172301/

Abstract

The intestinal epithelial barrier (IEB) plays a critical role in health and disease by regulating the absorption of nutrients, electrolytes and water while preventing gut translocation of pathogens. A compromised intestinal barrier has been reported in Parkinson's disease (PD) further reinforcing the assumption that PD is a gut-brain axis disorder and suggesting that gut-derived factors may participate in disease development and/or progression. However, the diversity of methodology between existing studies on gut permeability in PD, especially regarding the methods used for the evaluation of the IEB, has led to diverging results and it is definitely too early to draw any definite conclusions. We envision novel approaches, such as intestinal organoids and confocal laser endomicroscopy that could be used to study more precisely the IEB in PD.

摘要

肠道上皮屏障（IEB）通过调节营养物质、电解质和水的吸收，同时防止病原体的肠道易位，在健康和疾病中发挥着关键作用。据报道，帕金森病（PD）患者存在肠道屏障受损的情况，这进一步强化了PD是一种肠-脑轴疾病的假设，并表明肠道衍生因子可能参与疾病的发生和/或进展。然而，现有关于PD肠道通透性的研究之间方法的多样性，尤其是在评估IEB所使用的方法方面，导致了结果的分歧，现在得出任何明确结论绝对还为时过早。我们设想了一些新的方法，如肠道类器官和共聚焦激光内镜显微镜，可用于更精确地研究PD中的IEB。