用于软性人工晶状体的紫外线吸收水凝胶材料的化学研究。

Chemical investigations of ultraviolet-absorbing hydrogel material for soft intraocular lenses.

作者信息

Chirila T V, Russo A V, Constable I J

机构信息

Lions Eye Institute, Perth, Western Australia.

出版信息

J Cataract Refract Surg. 1989 Sep;15(5):504-9. doi: 10.1016/s0886-3350(89)80106-3.

DOI:10.1016/s0886-3350(89)80106-3

PMID:2810083

Abstract

A poly(2-hydroxyethyl methacrylate) hydrogel material exhibiting ultraviolet-absorbing properties was synthesized by simultaneous polymerization, crosslinking, and covalent bonding of an available polymerizable absorber. The two-stage leaching experiments carried out by aqueous extraction and the analysis of the concentrated extracts by high resolution capillary gas chromatography showed very low levels of additive released through leaching action. This proves that the ultraviolet absorbers can be successfully incorporated by covalent bonding in soft hydrogel intraocular lenses.

摘要

通过可用的可聚合吸收剂的同时聚合、交联和共价键合，合成了一种具有紫外线吸收特性的聚甲基丙烯酸2-羟乙酯水凝胶材料。通过水萃取进行的两阶段浸出实验以及通过高分辨率毛细管气相色谱法对浓缩提取物的分析表明，通过浸出作用释放的添加剂水平非常低。这证明紫外线吸收剂可以通过共价键成功地结合到软性水凝胶人工晶状体中。