Nishiyama Naotaka, Ikehata Yoshinori, Okuno Noriko, Sasahara Masakiyo, Sakamaki Ippei, Yamamoto Yoshihiro, Kitamura Hiroshi
Department of Urology, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama, 930-0194 Japan.
Department of Pathology, Faculty of Medicine, University of Toyama, Toyama, Japan.
Int Cancer Conf J. 2020 Sep 30;10(1):59-62. doi: 10.1007/s13691-020-00448-w. eCollection 2021 Jan.
A 68-year-old man was diagnosed with non-muscle-invasive bladder cancer and underwent transurethral resection of the bladder tumor (TURBT) in June 2014. The pathological diagnosis was urothelial carcinoma (UC), Grade 2, pT1. He was treated with intravesical bacillus Calmette-Guérin (BCG) instillation after TURBT. In February 2016, he received anti-tuberculosis treatment for systemic BCG infection, and tuberculosis treatment was continued. In September 2018, he presented with bilateral scrotum swelling and underwent bilateral orchiectomy following a diagnosis of antituberculotics-resistant epididymitis. The pathological findings were metastatic UC of the bilateral epididymis and testis. One months later, fluorodeoxyglucose-positron emission tomography/computed tomography showed para-aortic lymph node and peritoneal metastases. He was treated with chemotherapy of gemcitabine and cisplatin. We herein report a very rare case of synchronous metastatic UC of the bilateral epididymis and testis after intravesical BCG treatment.
一名68岁男性被诊断为非肌层浸润性膀胱癌，并于2014年6月接受了经尿道膀胱肿瘤切除术（TURBT）。病理诊断为尿路上皮癌（UC），2级，pT1。TURBT术后他接受了膀胱内卡介苗（BCG）灌注治疗。2016年2月，他因全身性BCG感染接受了抗结核治疗，并持续进行抗结核治疗。2018年9月，他出现双侧阴囊肿胀，在诊断为耐抗结核药附睾炎后接受了双侧睾丸切除术。病理结果为双侧附睾和睾丸转移性UC。1个月后，氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描显示腹主动脉旁淋巴结和腹膜转移。他接受了吉西他滨和顺铂化疗。我们在此报告一例膀胱内BCG治疗后双侧附睾和睾丸同步转移性UC的非常罕见病例。
