Shahrokh-Tehraninejad Ensieh, Dashti Minoo, Hossein-Rashidi Batool, Azimi-Nekoo Elham, Haghollahi Fedyeh, Kalantari Vahid
Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Sint Maarten School of Medicine, American University of Integrative Sciences, Cole Bay, Sint Maarten.
J Family Reprod Health. 2016 Sep;10(3):108-114.
Repeated implantation failure (RIF) is a condition in which the embryos implantation decreases in the endometrium. So, our aim was to evaluate the effect of local endometrial injury on embryo transfer results. In this simple randomized clinical trial (RCT), a total of 120 patients were selected. The participants were less than 40 years old, and they are in their minimum two cycles of vitro fertilization (IVF). Patients were divided randomly into two groups of LEI (Local endometrial injury) and a control group (n = 60 in each group). The first group had four small endometrial injuries from anterior, posterior, and lateral uterus walls which were obtained from people who were in 21 day of their previous IVF cycle. The second group was the patients who have not received any intervention. The experimental and control patients were matched in the following factors. Regarding the clinical pregnancy rate, there was no significant difference noted between the experimental and the control group. Local endometrial injury in a preceding cycle does not increase the clinical pregnancy rate in the subsequent FET cycle of patients with repeated implantation failure.
反复种植失败（RIF）是一种胚胎在子宫内膜着床率降低的情况。因此，我们的目的是评估局部子宫内膜损伤对胚胎移植结果的影响。在这项简单随机临床试验（RCT）中，共选取了120例患者。参与者年龄小于40岁，且至少经历过两个体外受精（IVF）周期。患者被随机分为局部子宫内膜损伤（LEI）组和对照组（每组n = 60）。第一组在前一个IVF周期的第21天，从子宫前壁、后壁和侧壁进行了四次小的子宫内膜损伤。第二组是未接受任何干预的患者。试验组和对照组患者在以下因素上进行了匹配。关于临床妊娠率，试验组和对照组之间未观察到显著差异。在前一周期进行局部子宫内膜损伤并不能提高反复种植失败患者后续冻融胚胎移植（FET）周期的临床妊娠率。
