Matoba Yusuke, Kisu Iori, Saotome Keiko, Katayama Motoko, Taniguchi Makiko, Miura Yumiko, Goto Taeko, Hirao Nobumaru
Department of Obstetrics and Gynecology, Federation of National Public Service Personnel Mutual Aid Associations, Tachikawa Hospital, Tokyo 190-0022, Japan; Department of Obstetrics and Gynecology, Keio University School of Medicine, Keio University, Tokyo 160-8582, Japan.
Department of Obstetrics and Gynecology, Federation of National Public Service Personnel Mutual Aid Associations, Tachikawa Hospital, Tokyo 190-0022, Japan.
Mol Clin Oncol. 2016 Dec;5(6):701-704. doi: 10.3892/mco.2016.1048. Epub 2016 Oct 11.
Uterine carcinoma of the lower uterine segment (LUS) is a rare tumor that accounts for 3-3.5% of cases of uterine malignant cancer. The tumor arises from the lower region of the uterine body through the upper region of the cervix. The present study reported a case of clear cell carcinoma that originated from the LUS. A 50-year-old woman visited a local hospital due to irregular vaginal bleeding. She was suspected to have a uterine tumor and was referred to Tachikawa Hospital (Tokyo, Japan). Transvaginal ultrasound and magnetic resonance imaging revealed a uterine tumor from the lower region of the uterine body through the upper region of the cervix. Endocervical curettage revealed clear cell carcinoma. Based on a diagnosis of clear cell carcinoma of the LUS, radical hysterectomy was performed with bilateral salpingo-oophorectomy, paraaortic lymph node dissection and omentectomy. Macroscopically, the tumor was limited to the lower region of the uterine body through the upper region of the cervix in the resected uterus. Histopathological findings indicated no tumors in the uterine corpus and uterine cervix, but clear cell carcinoma was observed in the LUS epithelium. At the 1-year follow-up, the patient remained free of local recurrence and metastasis. To the best of our knowledge, clear cell carcinoma of the LUS has not previously been reported. More cases are required to clarify the pathology.
子宫下段癌是一种罕见的肿瘤，占子宫恶性肿瘤病例的3%-3.5%。该肿瘤起源于子宫体下部并延伸至宫颈上部。本研究报告了一例起源于子宫下段的透明细胞癌病例。一名50岁女性因阴道不规则出血前往当地医院就诊。她被怀疑患有子宫肿瘤，并被转诊至立川医院（日本东京）。经阴道超声和磁共振成像显示子宫体下部至宫颈上部存在一个子宫肿瘤。宫颈管刮除术显示为透明细胞癌。基于子宫下段透明细胞癌的诊断，实施了根治性子宫切除术，同时进行双侧输卵管卵巢切除术、腹主动脉旁淋巴结清扫术和大网膜切除术。大体检查发现，切除子宫中的肿瘤局限于子宫体下部至宫颈上部区域。组织病理学检查结果显示子宫体和宫颈未发现肿瘤，但在子宫下段上皮中观察到透明细胞癌。在1年的随访中，患者未出现局部复发和转移。据我们所知，此前尚未有子宫下段透明细胞癌的报道。需要更多病例来阐明其病理学特征。
