使用全向观察导管的腔内激光散斑流变学
Intraluminal laser speckle rheology using an omni-directional viewing catheter.
作者信息
Wang Jing, Hosoda Masaki, Tshikudi Diane M, Hajjarian Zeinab, Nadkarni Seemantini K
机构信息
Wellman Center for Photomedicine, Harvard Medical School and Massachusetts General Hospital, MA 02114, USA; Authors contributed equally to this work.
Wellman Center for Photomedicine, Harvard Medical School and Massachusetts General Hospital, MA 02114, USA; Healthcare Optics Research Laboratory, Canon U.S.A., Inc., Cambridge, MA 02139, USA; Authors contributed equally to this work.
出版信息
Biomed Opt Express. 2016 Dec 8;8(1):137-150. doi: 10.1364/BOE.8.000137. eCollection 2017 Jan 1.
A number of disease conditions in luminal organs are associated with alterations in tissue mechanical properties. Here, we report a new omni-directional viewing Laser Speckle Rheology (LSR) catheter for mapping the mechanical properties of luminal organs without the need for rotational motion. The LSR catheter incorporates multiple illumination fibers, an optical fiber bundle and a multi-faceted mirror to permit omni-directional viewing of the luminal wall. By retracting the catheter using a motor-drive assembly, cylindrical maps of tissue mechanical properties are reconstructed. Evaluation conducted in a test phantom with circumferentially-varying mechanical properties demonstrates the capability of the LSR catheter for the accurate mechanical assessment of luminal organs.
管腔器官中的许多疾病状况都与组织力学特性的改变有关。在此，我们报告一种新型的全向观察激光散斑流变学（LSR）导管，用于绘制管腔器官的力学特性，无需旋转运动。LSR导管包含多根照明光纤、一束光纤和一个多面镜，以实现对管腔壁的全向观察。通过使用电机驱动组件缩回导管，可重建组织力学特性的圆柱形图谱。在具有周向变化力学特性的测试模型中进行的评估证明了LSR导管对管腔器官进行准确力学评估的能力。
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