Leartprapun Nichaluk, Adie Steven G
Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, New York 14853, USA.
Present affiliation: Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Biomed Opt Express. 2022 Dec 16;14(1):208-248. doi: 10.1364/BOE.468932. eCollection 2023 Jan 1.
Optical elastography offers a rich body of imaging capabilities that can serve as a bridge between organ-level medical elastography and single-molecule biophysics. We review the methodologies and recent developments in optical coherence elastography, Brillouin microscopy, optical microrheology, and photoacoustic elastography. With an outlook toward maximizing the basic science and translational clinical impact of optical elastography technologies, we discuss potential ways that these techniques can integrate not only with each other, but also with supporting technologies and capabilities in other biomedical fields. By embracing cross-modality and cross-disciplinary interactions with these parallel fields, optical elastography can greatly increase its potential to drive new discoveries in the biomedical sciences as well as the development of novel biomechanics-based clinical diagnostics and therapeutics.
光学弹性成像提供了丰富的成像能力，可作为器官级医学弹性成像与单分子生物物理学之间的桥梁。我们回顾了光学相干弹性成像、布里渊显微镜、光学微流变学和光声弹性成像的方法及最新进展。展望如何最大化光学弹性成像技术的基础科学和临床转化影响，我们讨论了这些技术不仅可以相互整合，还能与其他生物医学领域的支持技术和能力相结合的潜在方式。通过与这些平行领域进行跨模态和跨学科的互动，光学弹性成像能够极大地提升其在生物医学科学中推动新发现以及基于生物力学的新型临床诊断和治疗方法发展的潜力。
