DZNE, German Center for Neurodegenerative Diseases, Sigmund-Freud Str 27, 53127, Bonn, Germany.
Curr Environ Health Rep. 2017 Mar;4(1):38-43. doi: 10.1007/s40572-017-0131-6.
Innovations in agriculture and medicine as well as industrial and domestic technologies are essential for the growing and aging global population. These advances generally require the use of novel natural or synthetic chemical agents with the potential to affect human health. Here, we attempt to highlight environmental chemicals and select drugs with the potential to exacerbate aging by directly affecting molecular aging cascades focusing particular attention on the brain. Finally, we call attention to some potential fruitful areas of research, particularly with advanced molecular profiling that could aid in prevention or mitigation of environmental chemical toxic influences in the periphery and the brain.
We briefly summarize new research and highlight a recent study designed to prospectively identify agrochemicals with the potential to induce neurological diseases and place these discoveries into the already rich neurodegeneration and aging literature. Collectively, the research reviewed briefly here highlight chemicals with the true potential to accelerate aging, particularly in the brain, by eliciting elevated free radical stress and mitochondrial dysfunction. We make general recommendations about improved methodological approaches toward identification and regulation of chemicals that are gerontogenic to the brain.
目的综述：农业和医学创新以及工业和家庭技术对于全球不断增长和老龄化的人口至关重要。这些进展通常需要使用新型天然或合成化学物质，这些物质有可能通过直接影响分子衰老级联来影响人类健康。在这里，我们试图强调环境化学物质和一些有可能通过直接影响分子衰老级联来加剧衰老的药物，特别关注大脑。最后，我们呼吁关注一些有前途的研究领域，特别是利用先进的分子分析技术，可以帮助预防或减轻环境化学物质对周围和大脑的毒性影响。
最新发现：我们简要总结了新的研究成果，并重点介绍了一项旨在前瞻性识别具有潜在诱导神经退行性疾病能力的农用化学品的最新研究，并将这些发现纳入到丰富的神经退行性变和衰老文献中。总的来说，这里简要综述的研究结果强调了一些化学物质具有真正加速衰老的潜力，特别是在大脑中，它们通过引发高水平的自由基应激和线粒体功能障碍来加速衰老。我们对改善用于鉴定和管理对大脑有潜在致衰老作用的化学物质的方法提出了一般性建议。
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