a Instituto de Investigación en Ciencias de la Alimentación (CIAL, CSIC-UAM) , Madrid , Spain.
Crit Rev Food Sci Nutr. 2018 Jul 3;58(10):1629-1649. doi: 10.1080/10408398.2016.1275519. Epub 2017 Oct 4.
Among the most promising strategies currently assayed against IgE-mediated allergic diseases stands the possibility of using immunomodulating peptides to induce oral tolerance toward offending food allergens or even to prevent allergic sensitization. This review focuses on the beneficial effects of food derived immunomodulating peptides on food allergy, which can be directly exerted in the intestinal tract or once being absorbed through the intestinal epithelial barrier to interact with immune cells. Food peptides influence intestinal homeostasis by maintaining and reinforcing barrier function or affecting intestinal cell-signalling to nearby immune cells and mucus secretion. In addition, they can stimulate cells of the innate and adaptive immune system while supressing inflammatory responses. Peptides represent an attractive alternative to whole allergens to enhance the safety and efficacy of immunotherapy treatments. The conclusions drawn from curative and preventive experiments in murine models are promising, although there is a need for more pre-clinical studies to further explore the immunomodulating strategy and its mechanisms and for a deeper knowledge of the peptide sequence and structural requirements that determine the immunoregulatory function.
在目前针对 IgE 介导的过敏性疾病的最有前途的策略中，有一种可能性是使用免疫调节肽来诱导对引起过敏的食物过敏原的口服耐受性，甚至预防过敏致敏。本文重点介绍了食物来源的免疫调节肽对食物过敏的有益作用，这些肽可以直接在肠道发挥作用，也可以在被肠道上皮屏障吸收后与免疫细胞相互作用。食物肽通过维持和加强屏障功能或影响肠道细胞向附近免疫细胞和粘液分泌的信号转导来影响肠道内稳态。此外，它们可以刺激先天和适应性免疫系统的细胞，同时抑制炎症反应。与整个过敏原相比，肽代表了一种有吸引力的替代物，可以增强免疫疗法治疗的安全性和有效性。从鼠模型的治愈和预防实验中得出的结论是有希望的，尽管需要进行更多的临床前研究来进一步探索免疫调节策略及其机制，以及更深入地了解决定免疫调节功能的肽序列和结构要求。
