Aryan Zahra, Rezaei Nima, Camargo Carlos A
a Students' Scientific Research Center, Tehran University of Medical Sciences , Tehran , Iran.
b Department of Public Health , Tehran University of Medical Sciences , Tehran , Iran.
Int Rev Immunol. 2017 Jan 2;36(1):41-53. doi: 10.1080/08830185.2016.1272600. Epub 2017 Jan 19.
The role of vitamin D status in the etiology of allergic diseases is uncertain. The aim of this study was to investigate the association of vitamin D status with risk of two main outcomes: aeroallergen sensitization and allergic rhinitis (AR).
We performed a systematic review of Medline, Scopus, Science Citation Index, and Google Scholar databases. Studies were included if they reported on prevalent or incident cases of aeroallergen sensitization or AR according to vitamin D status. Quality assessment, data extraction and meta-analysis were performed.
A total of 21 observational studies were included. Children with serum 25(OH)D ≥75 nmol/L had significantly reduced odds of aeroallergen sensitization, but neither vitamin D intake in pregnancy nor vitamin D supplementation in infancy were associated with risk of AR. Individuals with serum 25(OH)D ≥75 nmol/L had lower prevalence of AR compared to those with serum 25(OH)D <50 nmol/L (OR; 0.71, 95%CI; (0.56-0.89), p = 0.04). This association was mainly observed in adult men; prevalence of AR was lower in men with serum 25(OH)D ≥75 nmol/L compared to men with serum 25(OH)D <50 nmol/L, while this association was not observed in women.
The current literature suggests significant age- and sex-specific relations of vitamin D status to risk of aeroallergen sensitization and AR.
维生素D状态在过敏性疾病病因学中的作用尚不确定。本研究旨在调查维生素D状态与两个主要结局风险之间的关联：吸入性变应原致敏和过敏性鼻炎（AR）。
我们对Medline、Scopus、科学引文索引和谷歌学术数据库进行了系统综述。如果研究报告了根据维生素D状态的吸入性变应原致敏或AR的患病率或发病率，则纳入研究。进行了质量评估、数据提取和荟萃分析。
共纳入21项观察性研究。血清25(OH)D≥75 nmol/L的儿童吸入性变应原致敏几率显著降低，但孕期维生素D摄入量和婴儿期维生素D补充剂与AR风险均无关联。血清25(OH)D≥75 nmol/L的个体与血清25(OH)D<50 nmol/L的个体相比，AR患病率更低（比值比；0.71，95%置信区间；(0.56 - 0.89)，p = 0.04）。这种关联主要在成年男性中观察到；血清25(OH)D≥75 nmol/L的男性与血清25(OH)D<50 nmol/L的男性相比，AR患病率更低，而在女性中未观察到这种关联。
当前文献表明维生素D状态与吸入性变应原致敏和AR风险之间存在显著的年龄和性别特异性关系。
