Ju Fei, Zhu Ruonan
Department of Otolaryngology the First Hospital of China Medical University, Shenyang, Liaoning, 110001, China.
Heliyon. 2023 Jun 14;9(6):e17283. doi: 10.1016/j.heliyon.2023.e17283. eCollection 2023 Jun.
Allergic rhinitis (AR) is a most common allergic condition characterised by cough, sneezing and flu-like symptoms. The aetiology of AR is not known. A deficiency of vitamin D has been associated with various allergic diseases. The role of vitamin D in allergic rhinitis has been explored in different populations, but the results remained inconsistent. Furthermore, vitamin D exerts its effect through the vitamin D receptor (VDR), and genetic variations in the VDR gene significantly alter vitamin D. We performed a meta-analysis to investigate the role of vitamin D levels and VDR polymorphisms with a predisposition to the development of AR.
All published articles were searched using databases such as PubMed, Google Scholar, and Science Direct. Based on rigorous inclusion and exclusion, appropriate studies were identified. Vitamin D levels, VDR genotype and allele frequencies were extracted from the eligible reports. The meta-analysis was performed by comprehensive meta-analysis software v3.3.
The present meta-analysis comprised 14 reports with 1504 AR patients and 1435 healthy controls. Compared to healthy controls, AR had significantly lower levels of vitamin D (P = 0.000, standard difference of means = -1.287, 95% CI = -1.921 to -0.652). The meta-analysis of two separate investigations, which included 917 cases and 847 controls, showed no predisposition to allergic rhinitis. The trial sequential analysis also demonstrated the need for future case-control studies of VDR polymorphism to examine their involvement in AR.
Lower vitamin D levels are associated with allergic rhinitis, and vitamin D supplementation might be advantageous in addition to standard treatment. The connection of VDR polymorphism (rs2228570) remained equivocal, and additional research is needed.
Vitamin D exerct its beneficial effect through the vitamin D receptor (VDR) and role of vitamin D and VDR variant in the allergic rhinitis has been contradictories. We performed a meta-analysis to draw a definitive conclusion of importance of vitamin D and VDR polymorphisms in predisposition to development of allergic rhinitis. The observations of the meta-analysis revealed a significant association of lower vitamin D with allergic rhinitis. In addition the VDR rs2228570 variant predisposed subject to develop rhinitis. Collectively, the results of the present investigation redirect requirement of individualized vitamin D supplementation in the management of allergic rhinitis.
变应性鼻炎（AR）是一种最常见的变态反应性疾病，其特征为咳嗽、打喷嚏和流感样症状。AR的病因尚不清楚。维生素D缺乏与多种变态反应性疾病有关。维生素D在变应性鼻炎中的作用已在不同人群中进行了探索，但结果仍不一致。此外，维生素D通过维生素D受体（VDR）发挥作用，VDR基因的遗传变异会显著改变维生素D的作用。我们进行了一项荟萃分析，以研究维生素D水平和VDR基因多态性在AR发病易感性中的作用。
使用PubMed、谷歌学术和科学Direct等数据库检索所有已发表的文章。根据严格的纳入和排除标准，确定合适的研究。从符合条件的报告中提取维生素D水平、VDR基因型和等位基因频率。荟萃分析由综合荟萃分析软件v3.3进行。
本荟萃分析纳入了14篇报告，涉及1504例AR患者和1435例健康对照。与健康对照相比，AR患者的维生素D水平显著较低（P = 0.000，均值标准差 = -1.287，95%可信区间 = -1.921至 -0.652）。两项单独调查的荟萃分析（包括917例病例和847例对照）显示，VDR基因多态性与变应性鼻炎发病无相关性。试验序贯分析也表明，未来需要进行VDR基因多态性的病例对照研究，以检查其在AR中的作用。
较低的维生素D水平与变应性鼻炎有关，除标准治疗外，补充维生素D可能有益。VDR基因多态性（rs2228570）与变应性鼻炎的关系仍不明确，需要进一步研究。
维生素D通过维生素D受体（VDR）发挥有益作用，维生素D和VDR变异在变应性鼻炎中的作用一直存在矛盾。我们进行了一项荟萃分析，以得出关于维生素D和VDR基因多态性在变应性鼻炎发病易感性中重要性的明确结论。荟萃分析的观察结果显示，较低的维生素D水平与变应性鼻炎之间存在显著关联。此外，VDR rs2228570变异使受试者易患鼻炎。总体而言，本研究结果重新导向了变应性鼻炎管理中个性化补充维生素D的需求。
