Calcinotto Arianna, Alimonti Andrea
Institute of Research in Oncology, Bellinzona, Switzerland.
Swiss Med Wkly. 2017 Jan 17;147:w14367. doi: 10.57187/smw.2017.14367. eCollection 2017.
Robust scientific evidence demonstrates that senes-cence induction in cancer works as a potent weapon to eradicate tumorigenesis. Therapies that enhance senescence not only promote a stable cell growth arrest but also work as a strong stimulus for the acti-vation of the antitumour immune response. However, recent advances suggest that if senescent tumour cells are not cleared from the tumours, they may promote tumour progression and metastasis. In this article, we focus on concepts that are relevant to a pro-senescence therapeutic approach, including caveats, and we propose therapeutic strategies that involve the combined use of pro-senescence therapies with im-munotherapies to promote the clearance of senescent tumour cells. In our opinion, these approaches may avoid potential negative effects of pro-senescence therapies and may also enhance the efficacy of cur-rently available immunotherapies.
强有力的科学证据表明，诱导癌症细胞衰老可作为根除肿瘤发生的有力武器。增强细胞衰老的疗法不仅能促进细胞生长稳定停滞，还能强烈刺激抗肿瘤免疫反应的激活。然而，最近的进展表明，如果衰老的肿瘤细胞未从肿瘤中清除，它们可能会促进肿瘤进展和转移。在本文中，我们关注与促衰老治疗方法相关的概念，包括注意事项，并提出将促衰老疗法与免疫疗法联合使用以促进衰老肿瘤细胞清除的治疗策略。我们认为，这些方法可能避免促衰老疗法的潜在负面影响，还可能提高现有免疫疗法的疗效。
