Aleksandrova Yulia, Neganova Margarita
Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Vavilova St. 28, Bld. 1, Moscow 119991, Russia.
Antioxidants (Basel). 2025 Feb 10;14(2):199. doi: 10.3390/antiox14020199.
Aging is a general biological process inherent in all living organisms. It is characterized by progressive cellular dysfunction. For many years, aging has been widely recognized as a highly effective mechanism for suppressing the progression of malignant neoplasms. However, in recent years, increasing evidence suggests a "double-edged" role of aging in cancer development. According to these data, aging is not only a tumor suppressor that leads to cell cycle arrest in neoplastic cells, but also a cancer promoter that ensures a chronic proinflammatory and immunosuppressive microenvironment. In this regard, in our review, we discuss recent data on the destructive role of senescent cells in the pathogenesis of cancer. We also identify for the first time correlations between the modulation of the senescence-associated secretory phenotype and the antitumor effects of naturally occurring molecules.
衰老 是所有生物体内固有的一个普遍生物学过程。其特征是细胞功能逐渐失调。多年来，衰老一直被广泛认为是抑制恶性肿瘤进展的一种高效机制。然而，近年来，越来越多的证据表明衰老在癌症发展中具有 “双刃剑” 作用。根据这些数据，衰老不仅是一种导致肿瘤细胞细胞周期停滞的肿瘤抑制因子，也是一种确保慢性促炎和免疫抑制微环境的癌症促进因子。在这方面，在我们的综述中，我们讨论了衰老细胞在癌症发病机制中的破坏作用的最新数据。我们还首次确定了衰老相关分泌表型的调节与天然分子的抗肿瘤作用之间的相关性。
