Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston MA 02215, USA.
Nat Rev Cancer. 2011 Jun 24;11(7):503-11. doi: 10.1038/nrc3057.
Abundant evidence points to a crucial physiological role for cellular senescence in combating tumorigenesis. Thus, the engagement of senescence may represent a key component for therapeutic intervention in the eradication of cancer. In this Opinion article, we focus on concepts that are relevant to a pro-senescence approach to therapy and we propose potential therapeutic strategies that aim to enhance the pro-senescence response in tumours.
大量证据表明细胞衰老在对抗肿瘤发生方面起着至关重要的生理作用。因此，衰老的发生可能代表着消除癌症的治疗干预的关键组成部分。在这篇观点文章中，我们专注于与衰老促进疗法相关的概念，并提出旨在增强肿瘤中衰老促进反应的潜在治疗策略。
