Maese Luke, Li K David, Xu Xinjie, Afify Zeinab, Paxton Christian N, Putnam Angelica
a Department of Pediatrics , University of Utah School of Medicine , Salt Lake City , Utah , USA.
b Division of Hematology/Oncology , Primary Children's Hospital , Salt Lake City , Utah , USA.
Fetal Pediatr Pathol. 2017 Apr;36(2):168-176. doi: 10.1080/15513815.2016.1273983. Epub 2017 Jan 19.
There is a known association of primary nonseminomatous mediastinal germ cell tumors (NSMGCT) and hematologic malignancy in younger males not linked to treatment. When combined these two rare entities convey a very poor prognosis. Here we report a 16-year-old male with an anterior mediastinal mass diagnosed as a malignant germ cell tumor based on elevation of serologic markers. He was found to have acute leukemia with megakaryocytic differentiation several days later. We focus our report on the pathologic findings, including a review of the literature, and a novel molecular analysis of the germ cell tumor.
已知在年轻男性中，原发性非精原性纵隔生殖细胞肿瘤（NSMGCT）与血液系统恶性肿瘤存在关联，且与治疗无关。当这两种罕见情况同时出现时，预后非常差。在此，我们报告一名16岁男性，其前纵隔肿块根据血清学标志物升高被诊断为恶性生殖细胞肿瘤。几天后，他被发现患有伴有巨核细胞分化的急性白血病。我们的报告重点关注病理结果，包括文献综述以及对生殖细胞肿瘤的新型分子分析。
