一种用于核磁共振（NMR）噪声抑制的简单方法。
A simple method for NMR t noise suppression.
作者信息
Mo Huaping, Harwood John S, Yang Danzhou, Post Carol Beth
机构信息
Purdue Inter-Departmental NMR Facility (PINMRF), Purdue University, West Lafayette, IN 47907, USA; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA.
Purdue Inter-Departmental NMR Facility (PINMRF), Purdue University, West Lafayette, IN 47907, USA; Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA.
出版信息
J Magn Reson. 2017 Mar;276:43-50. doi: 10.1016/j.jmr.2016.12.014. Epub 2016 Dec 29.
t noise appears as random or semi-random spurious streaks along the indirect t (F1) dimension of a 2D or nD NMR spectrum. It can significantly downgrade spectral quality, especially for spectra with strong diagonal signals such as NOESY, because useful and weak cross-peaks can be easily buried under t noise. One of the significant contributing factors to t noise is unwanted and semi-random F2 signal modulation during t acquisition. As such, t noise from different acquisitions is unlikely to correlate with each other strongly. In the case of NOESY, co-addition of multiple spectra significantly reduces t noise compared with conventional acquisition with the same amount of total acquisition time and resolution.
t噪声在二维或多维核磁共振谱的间接t（F1）维度上表现为随机或半随机的杂散条纹。它会显著降低谱图质量，特别是对于像NOESY这样具有强对角线信号的谱图，因为有用的弱交叉峰很容易被t噪声掩盖。t噪声的一个重要促成因素是在t采集期间不需要的半随机F2信号调制。因此，来自不同采集的t噪声彼此之间不太可能有很强的相关性。在NOESY的情况下，与具有相同总采集时间和分辨率的传统采集相比，多个谱图的共同相加显著降低了t噪声。
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