Biologie des Organismes et Écosystèmes Aquatiques (BOREA) Muséum National D'histoire Naturelle, Sorbonne Université, Université de Caen-Normandie, Université des Antilles, CNRS-8067, IRD 207, Normandy University, F-75231 Paris, France.
UNICAEN, Sorbonne Université, MNHN, UA, CNRS, IRD, Biologie des Organismes et Ecosystèmes Aquatiques (BOREA), F-14032 Caen, France.
Mar Drugs. 2022 Aug 4;20(8):505. doi: 10.3390/md20080505.
The cuttlefish () is a Cephalopod mollusk that lives in the English Channel and breeds in coastal spawning grounds in spring. A previous work showed that the control of egg-laying is monitored by different types of regulators, among which neuropeptides play a major role. They are involved in the integration of environmental cues, and participate in the transport of oocytes in the genital tract and in the secretion of capsular products. This study addresses a family of neuropeptides recently identified and suspected to be involved in the control of the reproduction processes. Detected by mass spectrometry and immunocytochemistry in the nerve endings of the accessory sex glands of the females and ovary, these neuropeptides are also identified in the hemolymph of egg-laying females demonstrating that they also have a hormone-like role. Released in the hemolymph by the sub-esophageal mass, a region that innervates the genital tract and the neurohemal area of the vena cava, in in vitro conditions these neuropeptides modulated oocyte transport and capsular secretion. Finally, in silico analyses indicated that these neuropeptides, initially called FLGamide, had extensive structural homology with orcokinin B, which motivated their name change.
乌贼（Cuttlefish）是一种头足类软体动物，生活在英吉利海峡，春季在沿海产卵场繁殖。先前的一项工作表明，产卵的控制受不同类型的调节剂监测，其中神经肽起主要作用。它们参与环境线索的整合，并参与卵母细胞在生殖道中的运输以及囊泡产物的分泌。本研究涉及最近鉴定出的一类神经肽，这些神经肽被怀疑参与控制生殖过程。这些神经肽在雌性的副性腺和卵巢的神经末梢中通过质谱和免疫细胞化学检测到，在产卵雌性的血淋巴中也有发现，表明它们也具有激素样作用。它们由食管下神经节释放到血淋巴中，该神经节支配生殖道和腔静脉的神经血区，在体外条件下，这些神经肽调节卵母细胞的运输和囊泡分泌。最后，计算机分析表明，这些最初被称为 FLGamide 的神经肽与章鱼胺 B 具有广泛的结构同源性，这促使它们改了名。
