Brennan Gary P, Henshall David C
Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland,123 St. Stephens Green, Dublin D02 YN77, Ireland.
Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland,123 St. Stephens Green, Dublin D02 YN77, Ireland.
Neurosci Lett. 2018 Feb 22;667:47-52. doi: 10.1016/j.neulet.2017.01.017. Epub 2017 Jan 16.
Temporal lobe epilepsy is a common and often drug-resistant seizure disorder. The underlying pathological processes which give rise to the development of spontaneous seizures include neuroinflammation, cell loss, neurogenesis and dendritic abnormalities and many of these are driven by insult-induced changes in gene expression and gene expression regulation. MicroRNAs are powerful modulators of post-transcriptional gene expression which are dysregulated during epileptogenesis. The advent of locked nucleic acid (LNA) based inhibitory methods and mimic technology has facilitated in vivo functional assessment of these molecules in epilepsy. Here we review recent advances in our understanding of the role of these short non-coding RNAs in the pathophysiology of epilepsy.
颞叶癫痫是一种常见且通常耐药的癫痫发作性疾病。引发自发性癫痫发作的潜在病理过程包括神经炎症、细胞丢失、神经发生和树突异常，其中许多是由损伤诱导的基因表达和基因表达调控变化所驱动的。微小RNA是转录后基因表达的强大调节因子，在癫痫发生过程中失调。基于锁核酸（LNA）的抑制方法和模拟技术的出现，促进了对这些分子在癫痫中的体内功能评估。在此，我们综述了我们对这些短链非编码RNA在癫痫病理生理学中作用的最新认识进展。
