Division of Angiology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Section of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Int J Infect Dis. 2017 Feb;55:96-98. doi: 10.1016/j.ijid.2017.01.010. Epub 2017 Jan 16.
A 71year old female Caucasian farmer without any known immunosuppression presented with a painful ulcer of her right lower leg after a trauma caused by a wood billet. There was no response to empirical antibacterial treatment. An ulcer biopsy showed an invasive Candida infection of the soft tissue and leucocytoclastic vasculitis. Voriconazole treatment was followed by wound healing. Invasive Candida infection and localized Candida vasculitis represent a rare cause of persisting leg ulcers. The similar clinical picture of chronic venous leg ulcers might blur the true cause and refractory cases should therefore promptly be processed by histopathological diagnostics.
一位 71 岁的白人女性农民,无已知免疫抑制,因一块木柴造成的创伤后出现右小腿疼痛性溃疡,经验性抗菌治疗无效。溃疡活检显示软组织侵袭性念珠菌感染和白细胞碎裂性血管炎。伏立康唑治疗后伤口愈合。侵袭性念珠菌感染和局部念珠菌血管炎是导致持续性腿部溃疡的罕见原因。慢性静脉性腿部溃疡的类似临床表现可能会掩盖真正的病因,因此对于难治性病例应及时进行组织病理学诊断。