Gómez-Gaviria Manuela, Mora-Montes Héctor M
Departamento de Biología, División de Ciencias Naturales y Exactas, Campus Guanajuato, Universidad de Guanajuato, Guanajuato, Gto, México.
Infect Drug Resist. 2020 Jun 10;13:1673-1689. doi: 10.2147/IDR.S247944. eCollection 2020.
Fungal infections represent a constant and growing menace to human health, because of the emergence of new species as causative agents of diseases and the increment of antifungal drug resistance. Candidiasis is one of the most common fungal infections in humans and is associated with a high mortality rate when the fungi infect deep-seated organs. belongs to the group of candidiasis etiological agents, and although it is not isolated as frequently as other species, the infections caused by this organism are of special relevance in the clinical setting because of its intrinsic resistance to fluconazole. Here, we offer a thorough revision of the current literature dealing with this organism and the caused disease, focusing on its biological aspects, the host-fungus interaction, the diagnosis, and the infection treatment. Of particular relevance, we provide the most recent genomic information, including the gene prediction of some putative virulence factors, like proteases, adhesins, regulators of biofilm formation and dimorphism. Moreover, veterinary aspects and the exploration of natural products with anti- activity are also included.
真菌感染对人类健康构成持续且日益严重的威胁，这是由于新的致病真菌物种不断出现以及抗真菌药物耐药性增加所致。念珠菌病是人类最常见的真菌感染之一，当真菌感染深部器官时，其死亡率很高。 属于念珠菌病的病原体类别，尽管它不像其他 物种那样经常被分离出来，但由于该生物体对氟康唑具有内在抗性，因此由它引起的感染在临床环境中具有特殊意义。在此，我们对当前涉及该生物体及其所致疾病的文献进行了全面综述，重点关注其生物学特性、宿主与真菌的相互作用、诊断以及感染治疗。特别值得一提的是，我们提供了最新的基因组信息，包括一些假定毒力因子的基因预测，如蛋白酶、黏附素、生物膜形成调节剂和二态性相关因子。此外，还包括兽医方面以及具有抗 活性的天然产物的探索。
