中性粒细胞与淋巴细胞比值：一篇叙述性综述。
The neutrophil-to-lymphocyte ratio: a narrative review.
作者信息
Faria Sara Socorro, Fernandes Paulo César, Silva Marcelo José Barbosa, Lima Vladmir C, Fontes Wagner, Freitas-Junior Ruffo, Eterovic Agda Karina, Forget Patrice
机构信息
Mastology Program, Federal University of Uberlandia (UFU), Avenida Engenheiro Diniz 1178, Reitoria 3º Andar Uberlândia, Minas Gerais, Brazil.
Department of Medical Oncology, AC Camargo Cancer Center, R Professor Antônio Prudente, 211, Liberdade, São Paulo 01509, Brazil.
出版信息
Ecancermedicalscience. 2016 Dec 12;10:702. doi: 10.3332/ecancer.2016.702. eCollection 2016.
Abstract
Cellular-mediated inflammatory response, lymphocytes, neutrophils, and monocytes are increasingly being recognised as having an important role in tumorigenesis and carcinogenesis. In this context, studies have suggested that the neutrophil-to-lymphocyte ratio (NLR) can be used as an independent prognostic factor in a variety of cancers. Particularly in breast cancer, several studies have shown that a high NLR is associated with shorter survival. Because the NLR can be easily determined from the full blood count, it could potentially provide a simple and inexpensive test cancer prognosis. This review addresses the possibilities and limitations of using the NLR as a clinical tool for risk stratification helpful for individual treatment of breast cancer patients. The potential underlying phenomena and some perspectives are discussed.
摘要
细胞介导的炎症反应、淋巴细胞、中性粒细胞和单核细胞在肿瘤发生和癌变过程中所起的重要作用日益受到认可。在这种背景下，研究表明中性粒细胞与淋巴细胞比值（NLR）可作为多种癌症的独立预后因素。特别是在乳腺癌中，多项研究表明高NLR与较短生存期相关。由于NLR可通过全血细胞计数轻松测定，它有可能提供一种简单且廉价的癌症预后检测方法。本综述探讨了将NLR用作有助于乳腺癌患者个体化治疗的风险分层临床工具的可能性和局限性。文中还讨论了潜在的相关现象及一些观点。
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4
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7
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